PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24859482-6	2014	Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO).	celastrol	13-22	vascular endothelial growth factor A	Homo sapiens	86-120	
32116702-7	2020	Additionally, celastrol reduced the expression levels of the angiogenesis-related proteins CD31, vascular endothelial growth factor receptor (VEGFR) 2, angiopoietin (Ang) 2 and VEGFA, VM-related proteins ephrin type-A receptor (EphA) 2, and vascular endothelial (VE)-cadherin.	celastrol	14-23	vascular endothelial growth factor A	Homo sapiens	177-182	
25383959-3	2014	In this study, we reported for the first time that Celastrol could induce HIF-1alpha protein accumulation in multiple cancer cell lines in an oxygen-independent manner and that the enhanced HIF-1alpha protein entered the nucleus and promoted the transcription of the HIF-1 target genes VEGF and Glut-1.	celastrol	51-60	vascular endothelial growth factor A	Homo sapiens	286-290	
24859482-6	2014	Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO).	celastrol	13-22	vascular endothelial growth factor A	Homo sapiens	122-126	
24157922-11	2014	VEGF levels decreased by 64.8, 84.4 and 92.9% after coexposure to celastrol at 0.025, 0.05 and 0.1 muM, respectively, compared to LPS alone.	celastrol	66-75	vascular endothelial growth factor A	Homo sapiens	0-4	
22683631-0	2012	Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells.	celastrol	0-9	vascular endothelial growth factor A	Homo sapiens	53-57	
24157922-10	2014	Celastrol significantly downregulated LPS-induced TLR4 expression and inhibited LPS-induced VEGF secretion in LP-1 cells.	celastrol	0-9	vascular endothelial growth factor A	Homo sapiens	92-96	
22683631-3	2012	The aims of this study are to investigate the effects of Celastrol on VEGF-induced functional activity of BM-EPCs and to identify any mechanisms associated with this process.	celastrol	57-66	vascular endothelial growth factor A	Homo sapiens	70-74	
22683631-4	2012	Here, we show that Celastrol attenuates VEGF secretion in BM-EPCs in vitro.	celastrol	19-28	vascular endothelial growth factor A	Homo sapiens	40-44	
21168266-6	2011	Celastrol"s ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-kappaB, Notch-1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, topoisomerase II, potassium channels, and heat shock response has been reported.	celastrol	0-9	vascular endothelial growth factor A	Homo sapiens	175-179	
19719969-13	2009	Immunohistochemistry experiments further revealed that celastrol also decreased the level of VEGFR-1 and VEGFR-2 expression, but not the level of VEGF expression.	celastrol	55-64	vascular endothelial growth factor A	Homo sapiens	93-97	
20160026-6	2010	Furthermore, Celastrol abrogated VEGF-induced sprouting of the vessels from aortic rings and inhibited vascular formation in the Matrigel plug assay in vivo.	celastrol	13-22	vascular endothelial growth factor A	Homo sapiens	33-37	
20160026-8	2010	Celastrol suppressed the VEGF-induced activation of AKT, mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase (P70S6K).	celastrol	0-9	vascular endothelial growth factor A	Homo sapiens	25-29