PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33472404-9 2021 Furthermore, celastrol treatment ameliorated RV systolic pressure, hypertrophy, fibrosis, and dysfunction in hypoxia-induced PH in mice and SU5416/hypoxia-induced PH in rats with reduced Bsg, CyPA, and inflammatory cytokines in the hearts and lungs. celastrol 13-22 basigin (Ok blood group) Rattus norvegicus 187-190 33472404-10 2021 CONCLUSIONS: These results indicate that elevated Bsg in pressure-overloaded RV exacerbates RV dysfunction and that celastrol ameliorates RV dysfunction in PH model animals by suppressing Bsg and its ligand CyPA. celastrol 116-125 basigin (Ok blood group) Rattus norvegicus 188-191 33472404-11 2021 Thus, celastrol can be a novel drug for PH and RV failure that targets Bsg and CyPA. celastrol 6-15 basigin (Ok blood group) Rattus norvegicus 71-74