PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33282271-10	2020	Celastrol can inhibit the oxidative stress reaction and liver cell apoptosis via regulation Nrf2/HO-1 pathway in T2DM mice with NAFLD.	celastrol	0-9	heme oxygenase 1	Mus musculus	97-101	
29040966-0	2017	Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-kappaB pathways.	celastrol	16-25	heme oxygenase 1	Mus musculus	132-136	
29040966-7	2017	Our results demonstrated that celastrol might control macrophage polarization through modulating the cross-talk between the following three mechanisms: 1) suppressing LPS-induced activation of MAP kinases (e.g., ERK1/2, p38, JNK) in a concentration dependent manner; 2) attenuating LPS-induced nuclear translocation of NF-kappaB p65 subunit in a time dependent manner; 3) activating Nrf2 and subsequently inducing HO-1 expression.	celastrol	30-39	heme oxygenase 1	Mus musculus	414-418	
29040966-8	2017	HO-1 inhibitor SnPP diminished the inhibitory effects of celastrol on the activation of NF-kappaB pathway and the pro-inflammatory M1 macrophage polarization.	celastrol	57-66	heme oxygenase 1	Mus musculus	0-4	
34174395-12	2021	Collectively, our results suggest that up-regulation of HMOX-1 is required for the inhibitory effect of Cel on vascular calcification.	celastrol	104-107	heme oxygenase 1	Mus musculus	56-62	
21866174-9	2011	HSP32 (also called heme oxygenase-1, HO-1) is the primary mediator of the protective effect of celastrol.	celastrol	95-104	heme oxygenase 1	Mus musculus	0-5	
21866174-9	2011	HSP32 (also called heme oxygenase-1, HO-1) is the primary mediator of the protective effect of celastrol.	celastrol	95-104	heme oxygenase 1	Mus musculus	19-35	
21866174-9	2011	HSP32 (also called heme oxygenase-1, HO-1) is the primary mediator of the protective effect of celastrol.	celastrol	95-104	heme oxygenase 1	Mus musculus	37-41	
21866174-11	2011	Taken together, our data indicate that celastrol inhibits aminoglycoside ototoxicity via HSP32/HO-1 induction.	celastrol	39-48	heme oxygenase 1	Mus musculus	89-94	
21866174-11	2011	Taken together, our data indicate that celastrol inhibits aminoglycoside ototoxicity via HSP32/HO-1 induction.	celastrol	39-48	heme oxygenase 1	Mus musculus	95-99