PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22580602-9 2013 Alteration of MRP3, MRP4, hCNT1 and hCNT3 expression was observed in MUC4-KD cells, but only hCNT1 alteration was correlated to MUC4 expression and sensitivity to gemcitabine. gemcitabine 163-174 solute carrier family 28 member 1 Homo sapiens 93-98 25600708-0 2015 Defective hCNT1 transport contributes to gemcitabine chemoresistance in ovarian cancer subtypes: overcoming transport defects using a nanoparticle approach. gemcitabine 41-52 solute carrier family 28 member 1 Homo sapiens 10-15 25600708-4 2015 Radioactivity analysis identified hCNT1-mediated (3)H-gemcitabine transport in ovarian cancer cells to be significantly reduced compared with that of normal ovarian surface epithelial cells. gemcitabine 54-65 solute carrier family 28 member 1 Homo sapiens 34-39 25600708-6 2015 Retroviral expression of hCNT1 selectively rescued gemcitabine transport in cell lines representing serous, teratocarcinoma, and endometrioid subtypes, but not clear cell carcinoma (CCC). gemcitabine 51-62 solute carrier family 28 member 1 Homo sapiens 25-30 22580602-12 2013 This work describes a new mechanism of PC cell resistance to gemcitabine, in which the MUC4 mucin negatively regulates the hCNT1 transporter expression via the NF-kappaB pathway. gemcitabine 61-72 solute carrier family 28 member 1 Homo sapiens 123-128 22580602-13 2013 Altogether, these data point out to MUC4 and hCNT1 as potential targets to ameliorate the response of pancreatic tumors to gemcitabine treatment. gemcitabine 123-134 solute carrier family 28 member 1 Homo sapiens 45-50 14581375-0 2003 Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2",2"-difluorodeoxycytidine- induced cytotoxicity. gemcitabine 83-110 solute carrier family 28 member 1 Homo sapiens 74-79 22838949-5 2012 This study reports an association of formation clearance of 2 ,2 -difluoro-2 -deoxycytidine triphosphate, an active form of gemcitabine with SNPs within uptake transporters SLC28A1, SLC28A3 and SLC29A1. gemcitabine 124-135 solute carrier family 28 member 1 Homo sapiens 173-180 18538445-8 2009 CDA+435, and SLC28A1+1561 are worthy of further investigation as potential indicators of patient outcome after gemcitabine treatment. gemcitabine 111-122 solute carrier family 28 member 1 Homo sapiens 13-20 14978229-8 2004 The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05). gemcitabine 33-44 solute carrier family 28 member 1 Homo sapiens 72-76 14978229-8 2004 The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05). gemcitabine 33-44 solute carrier family 28 member 1 Homo sapiens 97-101 14978229-8 2004 The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05). gemcitabine 33-44 solute carrier family 28 member 1 Homo sapiens 97-101 14978229-8 2004 The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05). gemcitabine 33-44 solute carrier family 28 member 1 Homo sapiens 97-101 14978229-8 2004 The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05). gemcitabine 33-44 solute carrier family 28 member 1 Homo sapiens 97-101 22838949-2 2012 MATERIALS & METHODS: SNPs within nine gemcitabine pathway genes, namely CDA, CMPK, DCK, DCTD, NT5C2, NT5C3, SLC28A1, SLC28A3 and SLC29A1 were analyzed for association with gemcitabine pharmacokinetics. gemcitabine 42-53 solute carrier family 28 member 1 Homo sapiens 112-119 22644860-2 2012 The objectives of this study were to analyze interindividual variations in the cellular accumulation of gemcitabine and to examine the correlation between the uptake of gemcitabine and expression levels of CNT1 and ENT1 transporters. gemcitabine 169-180 solute carrier family 28 member 1 Homo sapiens 206-210 22644860-3 2012 Gemcitabine was a substrate for both CNT1 and ENT1 with higher affinity to CNT1 than to ENT1. gemcitabine 0-11 solute carrier family 28 member 1 Homo sapiens 37-41 22644860-3 2012 Gemcitabine was a substrate for both CNT1 and ENT1 with higher affinity to CNT1 than to ENT1. gemcitabine 0-11 solute carrier family 28 member 1 Homo sapiens 75-79 22644860-5 2012 Among these, the CNT1- and ENT1-mediated uptake of gemcitabine was 14.3- and 16.5-folds, respectively. gemcitabine 51-62 solute carrier family 28 member 1 Homo sapiens 17-21 22644860-6 2012 CNT1-mediated gemcitabine uptake showed a higher correlation with the CNT1 expression level than did ENT1-mediated uptake with ENT1 expression level. gemcitabine 14-25 solute carrier family 28 member 1 Homo sapiens 0-4 22644860-6 2012 CNT1-mediated gemcitabine uptake showed a higher correlation with the CNT1 expression level than did ENT1-mediated uptake with ENT1 expression level. gemcitabine 14-25 solute carrier family 28 member 1 Homo sapiens 70-74 22644860-7 2012 In conclusion, CNT1 seemed to be a major contributing factor to gemcitabine uptake in PBMCs and showed 14.3-fold inter-individual variations. gemcitabine 64-75 solute carrier family 28 member 1 Homo sapiens 15-19 21343396-2 2011 In this study, we discovered a role for the human concentrative nucleoside transporter-1 (hCNT1; SLC28A1), a high-affinity pyrimidine nucleoside transporter, in determining the chemosensitivity of human pancreatic cancer cells to gemcitabine, the drug used presently as a standard of care. gemcitabine 230-241 solute carrier family 28 member 1 Homo sapiens 50-88 21343396-2 2011 In this study, we discovered a role for the human concentrative nucleoside transporter-1 (hCNT1; SLC28A1), a high-affinity pyrimidine nucleoside transporter, in determining the chemosensitivity of human pancreatic cancer cells to gemcitabine, the drug used presently as a standard of care. gemcitabine 230-241 solute carrier family 28 member 1 Homo sapiens 90-95 21343396-2 2011 In this study, we discovered a role for the human concentrative nucleoside transporter-1 (hCNT1; SLC28A1), a high-affinity pyrimidine nucleoside transporter, in determining the chemosensitivity of human pancreatic cancer cells to gemcitabine, the drug used presently as a standard of care. gemcitabine 230-241 solute carrier family 28 member 1 Homo sapiens 97-104 21343396-4 2011 In addition, hCNT1-mediated (3)H-gemcitabine transport was lower in pancreatic cancer cell lines and correlated with cytotoxic IC(50) estimations of gemcitabine. gemcitabine 33-44 solute carrier family 28 member 1 Homo sapiens 13-18 21343396-4 2011 In addition, hCNT1-mediated (3)H-gemcitabine transport was lower in pancreatic cancer cell lines and correlated with cytotoxic IC(50) estimations of gemcitabine. gemcitabine 149-160 solute carrier family 28 member 1 Homo sapiens 13-18 21343396-5 2011 In contrast to gemcitabine-sensitive pancreatic cancer cell lines, MIA PaCa-2, a gemcitabine-resistant pancreatic cancer cell line, exhibited relatively restrictive, cell cycle-dependent hCNT1 expression and transport. gemcitabine 81-92 solute carrier family 28 member 1 Homo sapiens 187-192 21343396-6 2011 hCNT1 translation was suppressed in the late G1-enriched MIA PaCa-2 cell population possibly in an miRNA-dependent manner, which corresponded with the lowest hCNT1-mediated gemcitabine transport during this phase. gemcitabine 173-184 solute carrier family 28 member 1 Homo sapiens 0-5 21343396-6 2011 hCNT1 translation was suppressed in the late G1-enriched MIA PaCa-2 cell population possibly in an miRNA-dependent manner, which corresponded with the lowest hCNT1-mediated gemcitabine transport during this phase. gemcitabine 173-184 solute carrier family 28 member 1 Homo sapiens 158-163 21343396-9 2011 Pharmacological inhibition of hCNT1 degradation moderately increased cell surface hCNT1 expression and cellular gemcitabine transport in MIA PaCa-2 cells. gemcitabine 112-123 solute carrier family 28 member 1 Homo sapiens 30-35 21343396-10 2011 Constitutive hCNT1 expression reduced clonogenic survival of MIA PaCa-2 cells and steeply augmented gemcitabine transport and chemosensitization. gemcitabine 100-111 solute carrier family 28 member 1 Homo sapiens 13-18 20734919-5 2010 hCNT1 knockdown caused MDA-MB-231 cells to be less sensitive to Gemcitabine compared with wild type and control plasmid cells (25% killed vs 88% and 90%). gemcitabine 64-75 solute carrier family 28 member 1 Homo sapiens 0-5 19318496-2 2009 Human equilibrative nucleoside transporter 1 (hENT1) and human concentrative nucleoside transporter (hCNT) 1 and 3 are the major transporters responsible for 2",2"-difluoro-2-deoxycytidine (gemcitabine) uptake into cells. gemcitabine 158-188 solute carrier family 28 member 1 Homo sapiens 63-114 19318496-2 2009 Human equilibrative nucleoside transporter 1 (hENT1) and human concentrative nucleoside transporter (hCNT) 1 and 3 are the major transporters responsible for 2",2"-difluoro-2-deoxycytidine (gemcitabine) uptake into cells. gemcitabine 190-201 solute carrier family 28 member 1 Homo sapiens 63-114 14668133-5 2004 Apparent affinities were higher than for hCNT1, with apparent K(m) values of 1.5-6.3 microM for adenosine, uridine and gemcitabine, and 112 and 130 microM, respectively, for AZT and ddC. gemcitabine 119-130 solute carrier family 28 member 1 Homo sapiens 41-46 10996312-4 2000 Gemcitabine (a pyrimidine nucleoside-derived drug) but not fludarabine (a purine nucleoside-derived drug) induced currents in oocytes expressing the hCNT1 transporter. gemcitabine 0-11 solute carrier family 28 member 1 Homo sapiens 149-154 10547395-5 1999 We also used the two-electrode, voltage-clamp technique to investigate the electrophysiology of hCNT1-mediated gemcitabine transport. gemcitabine 111-122 solute carrier family 28 member 1 Homo sapiens 96-101 10547395-6 1999 RESULTS: Gemcitabine was transported by most of the tested proteins (the exceptions being the purine-selective rCNT2 and hCNT2), with the greatest uptake occurring in oocytes producing recombinant rCNT1 and hCNT1. gemcitabine 9-20 solute carrier family 28 member 1 Homo sapiens 207-212 10547395-7 1999 Influxes of gemcitabine mediated by hCNT1, hENT1, and hENT2 were saturable and conformed to Michaelis-Menten kinetics with apparent K(m) values of 24, 160, and 740 microM, respectively. gemcitabine 12-23 solute carrier family 28 member 1 Homo sapiens 36-41 10547395-9 1999 External application of gemcitabine to oocytes producing recombinant hCNT1 induced an inward current, which demonstrated that hCNT1 functions as a Na(+)/nucleoside co-transport protein and confirmed the transporter"s ability to transport gemcitabine. gemcitabine 24-35 solute carrier family 28 member 1 Homo sapiens 69-74 10547395-9 1999 External application of gemcitabine to oocytes producing recombinant hCNT1 induced an inward current, which demonstrated that hCNT1 functions as a Na(+)/nucleoside co-transport protein and confirmed the transporter"s ability to transport gemcitabine. gemcitabine 24-35 solute carrier family 28 member 1 Homo sapiens 126-131 10547395-9 1999 External application of gemcitabine to oocytes producing recombinant hCNT1 induced an inward current, which demonstrated that hCNT1 functions as a Na(+)/nucleoside co-transport protein and confirmed the transporter"s ability to transport gemcitabine. gemcitabine 238-249 solute carrier family 28 member 1 Homo sapiens 69-74 10547395-9 1999 External application of gemcitabine to oocytes producing recombinant hCNT1 induced an inward current, which demonstrated that hCNT1 functions as a Na(+)/nucleoside co-transport protein and confirmed the transporter"s ability to transport gemcitabine. gemcitabine 238-249 solute carrier family 28 member 1 Homo sapiens 126-131 14701834-1 2004 We previously reported that the human Na(+)/nucleoside transporter pyrimidine-preferring 1 (hCNT1) is electrogenic and transports gemcitabine and 5"-deoxy-5-fluorouridine, a precursor of the active drug 5-fluorouracil. gemcitabine 130-141 solute carrier family 28 member 1 Homo sapiens 92-97