PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24697238-7	2014	Ibrutinib also inhibited BCR-dependent secretion of the chemokines CCL3 and CCL4 by HCL cells.	ibrutinib	0-9	C-C motif chemokine ligand 3	Homo sapiens	67-71	
28036258-9	2017	Moreover, evaluation of the CCL3 and CCL4 levels may be helpful for selecting DLBCL patients likely to benefit from doxorubicin treatment in combination with the velcade or ibrutinib.	ibrutinib	173-182	C-C motif chemokine ligand 3	Homo sapiens	28-32	
34174847-9	2021	Further, Acalabrutinib, Zanubrutinib and Ibrutinib reduced MCL-cell chemotaxis with similar efficiency, due to their similar abilities to downmodulate chemokines, such as CCL3 and CCL4.	ibrutinib	41-50	C-C motif chemokine ligand 3	Homo sapiens	171-175	
32168755-8	2020	Therefore, we evaluated the oxygen consumption rates (OCR) of CLL cells and plasma chemokine (C-C motif) ligands 3 and 4 (CCL3/CCL4) levels from ibrutinib-treated patients and demonstrated decreased OCR similar to control B lymphocytes, suggesting that ibrutinib treatment resets the mitochondrial bioenergetics, while diminished CCL3/CCL4 levels indicate the down regulation of the BCR signaling pathway in CLL.	ibrutinib	145-154	C-C motif chemokine ligand 3	Homo sapiens	122-126	
32168755-8	2020	Therefore, we evaluated the oxygen consumption rates (OCR) of CLL cells and plasma chemokine (C-C motif) ligands 3 and 4 (CCL3/CCL4) levels from ibrutinib-treated patients and demonstrated decreased OCR similar to control B lymphocytes, suggesting that ibrutinib treatment resets the mitochondrial bioenergetics, while diminished CCL3/CCL4 levels indicate the down regulation of the BCR signaling pathway in CLL.	ibrutinib	145-154	C-C motif chemokine ligand 3	Homo sapiens	330-334	
24693884-6	2014	Furthermore, the chemokines CCL3 and CCL4 production from tumor cells were also found to be attenuated by ibrutinib treatment.	ibrutinib	106-115	C-C motif chemokine ligand 3	Homo sapiens	28-32