PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34750354-5 2021 We now show that the BTKi ibrutinib and a second-generation compound, acalabrutinib downregulate miRNAs located in the 14q32 miRNA cluster region, including miR-494, miR-495, and miR-543. ibrutinib 26-35 microRNA 494 Homo sapiens 157-164 34750354-7 2021 Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression. ibrutinib 21-30 microRNA 494 Homo sapiens 169-176 34750354-7 2021 Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression. ibrutinib 87-96 microRNA 494 Homo sapiens 169-176