PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31828178-2	2019	Lack of CYP7B1 leads to an accumulation of its oxysterol substrates, in particular 25-hydroxycholesterol and 27-hydroxycholesterol that are able to cross the blood-brain barrier and have neurotoxic properties.	27-hydroxycholesterol	109-130	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14	
30586624-7	2019	In contrast the increase in levels of 27OH is likely to be a consequence of reduced metabolism due to loss of the neuronal enzyme CYP7B1.	27-hydroxycholesterol	38-42	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	130-136	
29126212-10	2017	Biochemically, marked accumulation of CYP7B1 substrates including 27-hydroxycholesterol was confirmed in serum (n = 19) and cerebrospinal fluid (n = 17) of SPG5 patients.	27-hydroxycholesterol	66-87	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	38-44	
32075687-2	2020	Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk.	27-hydroxycholesterol	89-93	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	41-70	
32075687-2	2020	Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk.	27-hydroxycholesterol	89-93	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	72-78	
32075687-2	2020	Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk.	27-hydroxycholesterol	241-245	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	72-78	
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	27-hydroxycholesterol	84-90	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150	
21541746-4	2012	Evaluation of the active site residues of the CYP7B1 model and validation of the active site architecture were performed via molecular docking experiments: the docking of the substrates 25-hydroxycholesterol and 27-hydroxycholesterol and the inhibitor 3alpha-Adiol identified structurally and functionally important residues.	27-hydroxycholesterol	212-233	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	46-52	
11971935-7	2002	Accumulation of 27-hydroxycholesterol in human atheroma is puzzling and may reflect low levels of oxysterol 7alpha-hydroxylase activity in human macrophages.	27-hydroxycholesterol	16-37	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	98-126	
10588945-4	1999	The human oxysterol 7alpha-hydroxylase transiently expressed in 293/T cells was able to catalyze 7alpha-hydroxylation of 27-hydroxycholesterol and dehydroepiandrosterone (DHEA).	27-hydroxycholesterol	121-142	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-38	
33345295-8	2021	We measured mRNA and protein levels of CYP7B1 in autopsy brain samples KEY RESULTS: The correlation between CSF-levels of 27OH and QAlb was higher in males while, with 7Hoca, the correlation was higher in females.	27-hydroxycholesterol	122-126	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	39-45	
31720082-0	2019	Recruitment of monocytes and epigenetic silencing of intratumoral CYP7B1 primarily contribute to the accumulation of 27-hydroxycholesterol in breast cancer.	27-hydroxycholesterol	117-138	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	66-72