PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33176848-1 2020 BACKGROUND: 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. 27-hydroxycholesterol 12-33 estrogen receptor 1 Homo sapiens 52-69 33368618-0 2021 27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 71-88 33176848-1 2020 BACKGROUND: 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. 27-hydroxycholesterol 35-39 estrogen receptor 1 Homo sapiens 52-69 31001203-7 2019 27-Hydroxycholesterol (27HC) acts as an endogenous selective estrogen receptor modulator and induces ERalpha-dependent HSC mobilization and extramedullary hematopoiesis. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 101-108 32075687-2 2020 Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk. 27-hydroxycholesterol 241-245 estrogen receptor 1 Homo sapiens 174-196 31001203-7 2019 27-Hydroxycholesterol (27HC) acts as an endogenous selective estrogen receptor modulator and induces ERalpha-dependent HSC mobilization and extramedullary hematopoiesis. 27-hydroxycholesterol 23-27 estrogen receptor 1 Homo sapiens 101-108 30016454-1 2019 BACKGROUND: 27-hydroxycholesterol (27HC) was the first identified endogenous selective estrogen receptor modulator (SERM); 27HC promoted growth and metastasis in experimental models of estrogen receptor-positive mammary cancer. 27-hydroxycholesterol 12-33 estrogen receptor 1 Homo sapiens 87-104 30016454-1 2019 BACKGROUND: 27-hydroxycholesterol (27HC) was the first identified endogenous selective estrogen receptor modulator (SERM); 27HC promoted growth and metastasis in experimental models of estrogen receptor-positive mammary cancer. 27-hydroxycholesterol 12-33 estrogen receptor 1 Homo sapiens 185-202 28442559-3 2017 27HC also acts as an endogenous selective estrogen receptor (ER) modulator capable of increasing breast cancer growth and metastasis. 27-hydroxycholesterol 0-4 estrogen receptor 1 Homo sapiens 42-59 29130512-0 2018 Hepatocyte-generated 27-hydroxycholesterol promotes the growth of melanoma by activation of estrogen receptor alpha. 27-hydroxycholesterol 21-42 estrogen receptor 1 Homo sapiens 92-115 29130512-4 2018 The cholesterol metabolite 27-hydroxy cholesterol (27-HC) catalyzed by CYP27A1 has been reported to activate estrogen receptor (ER). 27-hydroxycholesterol 27-49 estrogen receptor 1 Homo sapiens 109-126 29130512-4 2018 The cholesterol metabolite 27-hydroxy cholesterol (27-HC) catalyzed by CYP27A1 has been reported to activate estrogen receptor (ER). 27-hydroxycholesterol 27-49 estrogen receptor 1 Homo sapiens 128-130 29130512-4 2018 The cholesterol metabolite 27-hydroxy cholesterol (27-HC) catalyzed by CYP27A1 has been reported to activate estrogen receptor (ER). 27-hydroxycholesterol 51-56 estrogen receptor 1 Homo sapiens 109-126 29130512-4 2018 The cholesterol metabolite 27-hydroxy cholesterol (27-HC) catalyzed by CYP27A1 has been reported to activate estrogen receptor (ER). 27-hydroxycholesterol 51-56 estrogen receptor 1 Homo sapiens 128-130 29579190-4 2018 In the present study, we demonstrate that the first reported endogenous SERM, 27-hydroxycholesterol (27-OHC), binds preferentially (>100-fold) to ERbeta over ERalpha. 27-hydroxycholesterol 78-99 estrogen receptor 1 Homo sapiens 161-168 29579190-4 2018 In the present study, we demonstrate that the first reported endogenous SERM, 27-hydroxycholesterol (27-OHC), binds preferentially (>100-fold) to ERbeta over ERalpha. 27-hydroxycholesterol 101-107 estrogen receptor 1 Homo sapiens 161-168 28442559-3 2017 27HC also acts as an endogenous selective estrogen receptor (ER) modulator capable of increasing breast cancer growth and metastasis. 27-hydroxycholesterol 0-4 estrogen receptor 1 Homo sapiens 61-63 27151575-2 2016 Structural data suggest that cholesterol metabolites, including 27-hydroxycholesterol (27HC), can act as ERalpha ligands in these cells. 27-hydroxycholesterol 64-85 estrogen receptor 1 Homo sapiens 105-112 26877254-2 2017 27-Hydroxycholesterol (27-OHC) is associated with proliferation and metastasis in estrogen receptor positive (ER+) breast cancer. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 82-99 26877254-2 2017 27-Hydroxycholesterol (27-OHC) is associated with proliferation and metastasis in estrogen receptor positive (ER+) breast cancer. 27-hydroxycholesterol 23-29 estrogen receptor 1 Homo sapiens 82-99 27151575-2 2016 Structural data suggest that cholesterol metabolites, including 27-hydroxycholesterol (27HC), can act as ERalpha ligands in these cells. 27-hydroxycholesterol 87-91 estrogen receptor 1 Homo sapiens 105-112 26872310-4 2016 Moreover, 27-hydroxycholesterol, a locally produced cholesterol metabolite, reportedly promotes the proliferation of ERalpha breast cancer cells in vitro and facilitates tumor metastasis with other LXR ligands. 27-hydroxycholesterol 10-31 estrogen receptor 1 Homo sapiens 117-124 24210818-0 2013 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 48-50 26299212-1 2015 (25R)-26-Hydroxycholesterol (27-hydroxycholesterol) has been found to accumulate in breast tissue and to stimulate tumor growth via the estrogen receptor. 27-hydroxycholesterol 0-27 estrogen receptor 1 Homo sapiens 136-153 26299212-1 2015 (25R)-26-Hydroxycholesterol (27-hydroxycholesterol) has been found to accumulate in breast tissue and to stimulate tumor growth via the estrogen receptor. 27-hydroxycholesterol 29-50 estrogen receptor 1 Homo sapiens 136-153 26610607-6 2015 Mechanistically, CB sparks the constitutive activation of oestrogen receptors alpha (ERalpha) in AI-resistant cells, partly via the biosynthesis of 27-hydroxycholesterol. 27-hydroxycholesterol 148-169 estrogen receptor 1 Homo sapiens 85-92 25084324-6 2014 One of these ligands, 27-hydroxycholesterol (27HC), has been shown to manifest ER-dependent pathological activities in the cardiovascular system, bone and mammary gland. 27-hydroxycholesterol 22-43 estrogen receptor 1 Homo sapiens 79-81 25084324-6 2014 One of these ligands, 27-hydroxycholesterol (27HC), has been shown to manifest ER-dependent pathological activities in the cardiovascular system, bone and mammary gland. 27-hydroxycholesterol 45-49 estrogen receptor 1 Homo sapiens 79-81 21951066-6 2011 We specifically show that inhibition of ERbeta mediates 27-OHC-induced decrease in TH expression, an effect reversed by the ER agonist estradiol. 27-hydroxycholesterol 56-62 estrogen receptor 1 Homo sapiens 40-46 23313336-4 2013 However, other steroids, including Delta(5)-androstenediol, 5alpha-androstanediol and 27-hydroxycholesterol, which have a saturated A ring containing a 3beta-hydroxyl and a C19 methyl group, also mediate physiological responses through binding to estrogen receptor-alpha (ERalpha) and ERbeta. 27-hydroxycholesterol 86-107 estrogen receptor 1 Homo sapiens 247-270 23313336-4 2013 However, other steroids, including Delta(5)-androstenediol, 5alpha-androstanediol and 27-hydroxycholesterol, which have a saturated A ring containing a 3beta-hydroxyl and a C19 methyl group, also mediate physiological responses through binding to estrogen receptor-alpha (ERalpha) and ERbeta. 27-hydroxycholesterol 86-107 estrogen receptor 1 Homo sapiens 272-279 22932256-2 2012 The endogenous estrogen receptor antagonist 27-hydroxycholesterol (27OHC) is correlated with LDLC levels and may block the beneficial effects of estrogen on the cardiovascular system. 27-hydroxycholesterol 44-65 estrogen receptor 1 Homo sapiens 15-32 21951066-10 2011 Concomitant activation of ERbeta and inhibition of LXRbeta prevent 27-OHC effects and may therefore reduce the progression of Parkinson"s disease by precluding TH reduction and alpha-synuclein accumulation. 27-hydroxycholesterol 67-73 estrogen receptor 1 Homo sapiens 26-32 20501668-0 2010 The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 27-hydroxycholesterol 53-74 estrogen receptor 1 Homo sapiens 25-42 21420388-3 2011 Here, using an analysis of crystal structures of human ERalpha with E2 and other chemicals and 3D models of human ERalpha with 27-hydroxycholesterol and 5-androsten-3beta,17beta-diol, I propose that one or more Delta5 steroids were the ancestral ligands for the ER, with E2 evolving later as the canonical estrogen. 27-hydroxycholesterol 127-148 estrogen receptor 1 Homo sapiens 55-62 21420388-3 2011 Here, using an analysis of crystal structures of human ERalpha with E2 and other chemicals and 3D models of human ERalpha with 27-hydroxycholesterol and 5-androsten-3beta,17beta-diol, I propose that one or more Delta5 steroids were the ancestral ligands for the ER, with E2 evolving later as the canonical estrogen. 27-hydroxycholesterol 127-148 estrogen receptor 1 Homo sapiens 114-121 20501668-1 2010 Osteoporosis is an important clinical problem, affecting more than 50% of people over age 50 yr. Estrogen signaling is critical for maintaining proper bone density, and the identification of an endogenous selective estrogen receptor (ER) modulator, 27-hydroxycholesterol (27HC), suggests a mechanism by which nutritional/metabolic status can influence bone biology. 27-hydroxycholesterol 249-270 estrogen receptor 1 Homo sapiens 215-232 20501668-1 2010 Osteoporosis is an important clinical problem, affecting more than 50% of people over age 50 yr. Estrogen signaling is critical for maintaining proper bone density, and the identification of an endogenous selective estrogen receptor (ER) modulator, 27-hydroxycholesterol (27HC), suggests a mechanism by which nutritional/metabolic status can influence bone biology. 27-hydroxycholesterol 249-270 estrogen receptor 1 Homo sapiens 234-236 34556659-1 2021 27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 105-122 18722677-0 2008 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 59-76 18722677-3 2008 In support of this hypothesis is the recent demonstration that the oxysterol 27-hydroxycholesterol (27HC) interacts with and modulates the transcriptional activity of both estrogen receptor (ER) subtypes and that the relative agonist and antagonist activity of 27HC is influenced by both cell and promoter context. 27-hydroxycholesterol 77-98 estrogen receptor 1 Homo sapiens 172-189 18722677-3 2008 In support of this hypothesis is the recent demonstration that the oxysterol 27-hydroxycholesterol (27HC) interacts with and modulates the transcriptional activity of both estrogen receptor (ER) subtypes and that the relative agonist and antagonist activity of 27HC is influenced by both cell and promoter context. 27-hydroxycholesterol 77-98 estrogen receptor 1 Homo sapiens 191-193 18722677-3 2008 In support of this hypothesis is the recent demonstration that the oxysterol 27-hydroxycholesterol (27HC) interacts with and modulates the transcriptional activity of both estrogen receptor (ER) subtypes and that the relative agonist and antagonist activity of 27HC is influenced by both cell and promoter context. 27-hydroxycholesterol 100-104 estrogen receptor 1 Homo sapiens 172-189 18722677-3 2008 In support of this hypothesis is the recent demonstration that the oxysterol 27-hydroxycholesterol (27HC) interacts with and modulates the transcriptional activity of both estrogen receptor (ER) subtypes and that the relative agonist and antagonist activity of 27HC is influenced by both cell and promoter context. 27-hydroxycholesterol 100-104 estrogen receptor 1 Homo sapiens 191-193 34774482-5 2022 Recently, several studies have shown that 27-OHC can activate or inhibit the function of estrogen receptors ERalpha and ERbeta in a tissue-specific manner, indicating that the understanding of 27-OHC-mediated biological output is very complicated. 27-hydroxycholesterol 193-199 estrogen receptor 1 Homo sapiens 108-115 34774482-5 2022 Recently, several studies have shown that 27-OHC can activate or inhibit the function of estrogen receptors ERalpha and ERbeta in a tissue-specific manner, indicating that the understanding of 27-OHC-mediated biological output is very complicated. 27-hydroxycholesterol 193-199 estrogen receptor 1 Homo sapiens 120-126 17872378-0 2008 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 49-66 34556659-1 2021 27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. 27-hydroxycholesterol 23-27 estrogen receptor 1 Homo sapiens 105-122 35629858-6 2022 Instead of cholesterol, 27-hydroxycholesterol, which is a cholesterol metabolite, is thought to promote propagation and metastasis of estrogen receptor-positive breast cancer cell lines. 27-hydroxycholesterol 24-45 estrogen receptor 1 Homo sapiens 134-151 35326671-0 2022 27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer. 27-hydroxycholesterol 0-21 estrogen receptor 1 Homo sapiens 60-77