PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23428587-7 2013 Fasudil and sildenafil given alone or in combination caused a significant increase in plasma VEGF-A level as compared to rats exposed to MCT. Sildenafil Citrate 12-22 vascular endothelial growth factor A Rattus norvegicus 93-99 32959702-0 2021 Sildenafil ameliorates Alzheimer disease via the modulation of vascular endothelial growth factor and vascular cell adhesion molecule-1 in rats. Sildenafil Citrate 0-10 vascular endothelial growth factor A Rattus norvegicus 63-97 32959702-16 2021 These findings suggested a protective effect of sildenafil via modulation of VEGF-A, and VCAM-1. Sildenafil Citrate 48-58 vascular endothelial growth factor A Rattus norvegicus 77-83 29218089-4 2017 Moreover, sildenafil dramatically decreased the expression of transforming growth factor-beta1 (TGF-beta1), vascular endothelial growth factor (VEGF), and alpha-smooth muscle actin (alpha-SMA) in the grafted aortas and increased the concentrations of cyclic guanosine monophosphate (cGMP) and endothelial nitric oxide synthase (eNOS) in serum. Sildenafil Citrate 10-20 vascular endothelial growth factor A Rattus norvegicus 108-142 29218089-4 2017 Moreover, sildenafil dramatically decreased the expression of transforming growth factor-beta1 (TGF-beta1), vascular endothelial growth factor (VEGF), and alpha-smooth muscle actin (alpha-SMA) in the grafted aortas and increased the concentrations of cyclic guanosine monophosphate (cGMP) and endothelial nitric oxide synthase (eNOS) in serum. Sildenafil Citrate 10-20 vascular endothelial growth factor A Rattus norvegicus 144-148 25541842-8 2014 RESULTS: Sildenafil increased levels of Gpx, and Flt-1, and decreased MDA and VEGF levels in tissues. Sildenafil Citrate 9-19 vascular endothelial growth factor A Rattus norvegicus 78-82 25541842-9 2014 Sildenafil also increased serum levels of TAC and Flt-1 and decreased TOS, OSI, and VEGF. Sildenafil Citrate 0-10 vascular endothelial growth factor A Rattus norvegicus 84-88 24610727-16 2014 VEGF analysis trended toward increased VEGF for all sildenafil-treated groups (P > 0.05). Sildenafil Citrate 52-62 vascular endothelial growth factor A Rattus norvegicus 0-4 24610727-16 2014 VEGF analysis trended toward increased VEGF for all sildenafil-treated groups (P > 0.05). Sildenafil Citrate 52-62 vascular endothelial growth factor A Rattus norvegicus 39-43 33270292-8 2021 CONCLUSION: The present study demonstrated that sildenafil optimized bone tissue regeneration by increasing VEGF signaling and osteopontin expression, with increased bone formation (osteoid and carbohydrate macromolecule deposition) in the early stages following traumatic ischemic insult. Sildenafil Citrate 48-58 vascular endothelial growth factor A Rattus norvegicus 108-112 23065129-8 2013 Furthermore, the oxygen sensor hypoxia-inducible factor (HIF)-1/2alpha and the angiogenic factor vascular endothelial growth factor (VEGF) were highly expressed in the lungs of sildenafil-treated rats. Sildenafil Citrate 177-187 vascular endothelial growth factor A Rattus norvegicus 133-137 20487237-0 2010 Chronic administration of sildenafil modified the impaired VEGF system and improved the erectile function in rats with diabetic erectile dysfunction. Sildenafil Citrate 26-36 vascular endothelial growth factor A Rattus norvegicus 59-63 21190420-2 2011 The authors aimed to investigate the effect of sildenafil citrate (Sc) on expressions of beta(3) integrin and vascular endothelial growth factor (VEGF), which is taking part in endometrium receptivity in implantation window period in controlled ovarian hyperstimulation (COH) performed rats. Sildenafil Citrate 47-65 vascular endothelial growth factor A Rattus norvegicus 110-144 21190420-2 2011 The authors aimed to investigate the effect of sildenafil citrate (Sc) on expressions of beta(3) integrin and vascular endothelial growth factor (VEGF), which is taking part in endometrium receptivity in implantation window period in controlled ovarian hyperstimulation (COH) performed rats. Sildenafil Citrate 47-65 vascular endothelial growth factor A Rattus norvegicus 146-150 20487237-3 2010 AIM: To determine whether chronic sildenafil administration can modify the impaired vascular endothelial growth factor (VEGF) system and improve the erectile function in rats with diabetic erectile dysfunction. Sildenafil Citrate 34-44 vascular endothelial growth factor A Rattus norvegicus 84-118 20487237-3 2010 AIM: To determine whether chronic sildenafil administration can modify the impaired vascular endothelial growth factor (VEGF) system and improve the erectile function in rats with diabetic erectile dysfunction. Sildenafil Citrate 34-44 vascular endothelial growth factor A Rattus norvegicus 120-124 20487237-13 2010 CONCLUSION: We demonstrated that daily sildenafil administration can restore the impaired VEGF system in the penis of DMED rats and progressively improve both erectile function and endothelial function, suggesting a potential general mechanism of improved signaling through the VEGF/eNOS signaling cascade. Sildenafil Citrate 39-49 vascular endothelial growth factor A Rattus norvegicus 90-94 20487237-13 2010 CONCLUSION: We demonstrated that daily sildenafil administration can restore the impaired VEGF system in the penis of DMED rats and progressively improve both erectile function and endothelial function, suggesting a potential general mechanism of improved signaling through the VEGF/eNOS signaling cascade. Sildenafil Citrate 39-49 vascular endothelial growth factor A Rattus norvegicus 278-282 18443849-9 2008 The sildenafil-treated group showed a significant (p < 0.05) reduction in both areas at day 7 compared to the VEGF and control groups. Sildenafil Citrate 4-14 vascular endothelial growth factor A Rattus norvegicus 113-117 20583517-13 2010 In addition, sildenafil increased the expression of VEGF-A, VEGF-B, and VEGF-C by 2.66-, 2.02-, and 2.00-fold, respectively. Sildenafil Citrate 13-23 vascular endothelial growth factor A Rattus norvegicus 52-58 20583517-15 2010 These data demonstrate that sildenafil altered the expression of FGF and VEGF. Sildenafil Citrate 28-38 vascular endothelial growth factor A Rattus norvegicus 73-77 18373738-0 2008 Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin-1. Sildenafil Citrate 0-10 vascular endothelial growth factor A Rattus norvegicus 119-123 18373738-2 2008 Our study aimed to determine a novel role of sildenafil on cardioprotection through stimulating angiogenesis during ischaemia (I) reperfusion (R) at both capillary and arteriolar levels and to examine the role of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) in this mechanistic effect. Sildenafil Citrate 45-55 vascular endothelial growth factor A Rattus norvegicus 249-253 18373738-7 2008 Treatment with sildenafil demonstrated increased VEGF and Ang-1 mRNA after early reperfusion. Sildenafil Citrate 15-25 vascular endothelial growth factor A Rattus norvegicus 49-53 18373738-13 2008 Our study demonstrated for the first time a strong additional therapeutic potential of sildenafil by up-regulating VEGF and Ang-1 system, probably by stimulating a cascade of events leading to neovascularization and conferring myocardial protection in in vivo I/R rat model. Sildenafil Citrate 87-97 vascular endothelial growth factor A Rattus norvegicus 115-119