PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23226094-4 2012 Treatment of HNSCC cell lines with the newly developed TORC1/TORC2 inhibitor OSI-027/ASP4876 resulted in dose-dependent inhibition of proliferation with abrogation of phosphorylation of known downstream targets including phospho-AKT (Ser473), phospho-4E-BP1, phospho-p70s6K, and phospho-PRAS40. OSI 027 77-84 AKT1 substrate 1 Homo sapiens 287-293