PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34191473-0 2021 eIF2alpha-ATF4 Pathway Activated by a Change in the Calcium Environment Participates in BCP-Mediated Bone Regeneration. hydroxyapatite-beta tricalcium phosphate 88-91 activating transcription factor 4 Rattus norvegicus 10-14 34191473-6 2021 The results showed that the ERs and eIF2alpha-ATF4 pathway activation were observed during 4 weeks of bone repair, with a rapid but brief increase immediately after artificial defect surgery and a re-increase after 4 weeks with the resorption of BCP materials. hydroxyapatite-beta tricalcium phosphate 246-249 activating transcription factor 4 Rattus norvegicus 46-50 34191473-8 2021 In conclusion, the eIF2alpha-ATF4 pathway activated by a change in the calcium environment participates in BCP-mediated bone regeneration. hydroxyapatite-beta tricalcium phosphate 107-110 activating transcription factor 4 Rattus norvegicus 29-33 34191473-3 2021 Endoplasmic reticulum stress (ERs) and the subsequent PERK-eIF2alpha-ATF4 pathway can be activated by various factors, including trauma and intracellular calcium changes, and therefore worth exploring as a potential mechanism in BCP-mediated bone repair. hydroxyapatite-beta tricalcium phosphate 229-232 activating transcription factor 4 Rattus norvegicus 69-73