PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24801546-4	2014	We also investigated whether sulfuretin specifically acts by inhibiting phosphorylation of mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and glycogen synthase kinase-3beta (GSK-3beta) as well as activation of the nuclear factor-kappa B (NF-kappaB) pathway.	sulfuretin	29-39	glycogen synthase kinase 3 beta	Homo sapiens	178-208	
29257079-0	2017	Sulfuretin Attenuates MPP+-Induced Neurotoxicity through Akt/GSK3beta and ERK Signaling Pathways.	sulfuretin	0-10	glycogen synthase kinase 3 beta	Homo sapiens	61-69	
29257079-9	2017	Moreover, sulfuretin significantly increased the phosphorylation of Akt, GSK3beta, and ERK.	sulfuretin	10-20	glycogen synthase kinase 3 beta	Homo sapiens	73-81	
29257079-11	2017	An inhibitor of GSK3beta mimicked sulfuretin-induced protection against MPP+.	sulfuretin	34-44	glycogen synthase kinase 3 beta	Homo sapiens	16-24	
29257079-12	2017	Taken together, these results suggest that sulfuretin significantly attenuates MPP+-induced neurotoxicity through Akt/GSK3beta and ERK signaling pathways in SH-SY5Y cells.	sulfuretin	43-53	glycogen synthase kinase 3 beta	Homo sapiens	118-126	
24801546-4	2014	We also investigated whether sulfuretin specifically acts by inhibiting phosphorylation of mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and glycogen synthase kinase-3beta (GSK-3beta) as well as activation of the nuclear factor-kappa B (NF-kappaB) pathway.	sulfuretin	29-39	glycogen synthase kinase 3 beta	Homo sapiens	210-219	
24801546-7	2014	Moreover, sulfuretin significantly attenuated 6-OHDA-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase 1/2 (ERK 1/2) MAPKs, PI3K/Akt, and GSK-3beta.	sulfuretin	10-20	glycogen synthase kinase 3 beta	Homo sapiens	189-198	
24801546-9	2014	The results of the current study provide the first evidence that sulfuretin protects SH-SY5Y cells against 6-OHDA-induced neuronal cell death, possibly through inhibition of phosphorylation of MAPK, PI3K/Akt, and GSK-3beta, which leads to mitochondrial protection, NF-kappaB modulations and subsequent suppression of apoptosis via ROS-dependent pathways.	sulfuretin	65-75	glycogen synthase kinase 3 beta	Homo sapiens	213-222