PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24941853-9	2014	CONCLUSION: Ginsenoside Rc, Rf, Rb2, F2, F1, tanshinone I, and isoborneol in DC could induce CYP3A4 enzymes.	tanshinone	45-57	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99	
18805405-8	2009	Furthermore, CAR and GR were also involved in the induction of CYP3A4 expression by tanshinones, though their roles seemed not as important as PXR.	tanshinone	84-95	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-69	
24223062-7	2013	The in vitro study showed that dihydrotanshinone I in the extract could inhibit CYP3A, while tanshinone IIA and cryptotanshinone could induce CYP3A.	tanshinone	93-107	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-147	
20964620-0	2010	Activation of CYP3A-mediated testosterone 6beta-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes.	tanshinone	65-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-19	
20964620-1	2010	This study evaluated the in vitro activation of CYP3A-mediated midazolam 1-hydroxylation and testosterone 6beta-hydroxylation by tanshinone I, tanshinone IIA, and cryptotanshinone.	tanshinone	129-141	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-53	
20964620-1	2010	This study evaluated the in vitro activation of CYP3A-mediated midazolam 1-hydroxylation and testosterone 6beta-hydroxylation by tanshinone I, tanshinone IIA, and cryptotanshinone.	tanshinone	143-157	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-53	
20964620-2	2010	The abilities of tanshinones to activate CYP3A-mediated midazolam 1-hydroxylation and testosterone 6beta-hydroxylation in human liver microsomes (HLMs) were tested.	tanshinone	17-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-46	
20964620-3	2010	Substrate- and effector-dependent activation of CYP3A by tanshinones were both observed.	tanshinone	57-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-53	
20964620-6	2010	In addition, tanshinone IIA activated CYP3A-mediated testosterone 6beta-hydroxylation, whereas cryptotanshinone and tanshinone I did not.	tanshinone	13-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-43	
20964620-6	2010	In addition, tanshinone IIA activated CYP3A-mediated testosterone 6beta-hydroxylation, whereas cryptotanshinone and tanshinone I did not.	tanshinone	13-25	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-43	
20964620-7	2010	The results from our study enhance the understanding of CYP3A activation by tanshinone IIA and cryptotanshinone in HLMs.	tanshinone	76-90	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-61	
18805405-0	2009	PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.	tanshinone	74-88	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49	
18805405-9	2009	Treatment of LS174T cells with cryptotanshinone or tanshinone IIA resulted in a significant increase of CYP3A4 mRNA, which was consistent with the results from the reporter gene assay.	tanshinone	37-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-110