PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30854080-6	2019	In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL-27 and SCC-25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL-27 and SCC-25 cells, alongside decreased levels of caspase-3 and specific cleavage of poly (ADP-ribose) polymerase.	pristimerin	101-112	cyclin D1	Homo sapiens	246-255	
24603988-5	2014	The induction of apoptosis by PM was associated with the inhibition of the pro-survival Akt, NF-kappaB and mTOR signaling proteins and their downstream intermediaries such as Foxo-3alpha and cyclin D1 (Akt); Cox-2 and VEGF (NF-kappaB); p-S6K1 and p-4E-BP1 (mTOR) as well as PKCepsilon.	pristimerin	30-32	cyclin D1	Homo sapiens	191-200	
32347651-6	2020	Pristimerin inhibited Akt and FoxO3a phosphorylation and induced nuclear accumulation of FoxO3a in UM-1 cells, increased the expression of pro-apoptotic proteins Bim p27Kip1 , cleaved caspase-3, PARP and Bax, and decreased the expression of Cyclin D1 and Bcl-2.	pristimerin	0-11	cyclin D1	Homo sapiens	241-250