PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33770738-10 2021 CONCLUSION: OATP1B3 expression was associated with contrast grades of hepatocellular nodules observed in HBP image of gadoxetic acid-enhanced MRI in the hypovascular hepatocellular nodules and was negatively correlated with hepatocarcinogenesis. gadolinium ethoxybenzyl DTPA 118-132 solute carrier organic anion transporter family member 1B3 Homo sapiens 12-19 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). gadolinium ethoxybenzyl DTPA 180-238 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-124 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). gadolinium ethoxybenzyl DTPA 180-238 solute carrier organic anion transporter family member 1B3 Homo sapiens 126-133 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). gadolinium ethoxybenzyl DTPA 240-251 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-124 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). gadolinium ethoxybenzyl DTPA 240-251 solute carrier organic anion transporter family member 1B3 Homo sapiens 126-133 34445497-4 2021 We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically available near-infrared (NIR) fluorescent dye. gadolinium ethoxybenzyl DTPA 127-138 solute carrier organic anion transporter family member 1B3 Homo sapiens 32-81 34445497-7 2021 In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA. gadolinium ethoxybenzyl DTPA 157-168 solute carrier organic anion transporter family member 1B3 Homo sapiens 28-35 34445497-7 2021 In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA. gadolinium ethoxybenzyl DTPA 157-168 solute carrier organic anion transporter family member 1B3 Homo sapiens 112-119 32458127-6 2020 Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes. gadolinium ethoxybenzyl DTPA 161-175 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-101 33603462-0 2021 OATP1B3 Expression in Hepatocellular Carcinoma Correlates with Intralesional Gd-EOB-DTPA Uptake and Signal Intensity on Gd-EOB-DTPA-Enhanced MRI. gadolinium ethoxybenzyl DTPA 77-88 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-7 33603462-1 2021 Background: To evaluate the predictive value of the OATP1B3 expression in hepatocellular carcinoma (HCC) for the gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) uptake and the signal intensity (SI) in the hepatobiliary (HB) phase. gadolinium ethoxybenzyl DTPA 113-171 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-59 33603462-1 2021 Background: To evaluate the predictive value of the OATP1B3 expression in hepatocellular carcinoma (HCC) for the gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) uptake and the signal intensity (SI) in the hepatobiliary (HB) phase. gadolinium ethoxybenzyl DTPA 173-184 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-59 33603462-9 2021 Conclusion: The OATP1B3 expression in HCC can predict the uptake of Gd-EOB-DTPA and the SI of the HB phase. gadolinium ethoxybenzyl DTPA 68-79 solute carrier organic anion transporter family member 1B3 Homo sapiens 16-23 33707581-2 2021 Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers. gadolinium ethoxybenzyl DTPA 0-19 solute carrier organic anion transporter family member 1B3 Homo sapiens 38-45 33707581-2 2021 Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers. gadolinium ethoxybenzyl DTPA 0-19 solute carrier organic anion transporter family member 1B3 Homo sapiens 95-102 29050339-0 2017 Aberrant expression of OATP1B3 in colorectal cancer liver metastases and its clinical implication on gadoxetic acid-enhanced MRI. gadolinium ethoxybenzyl DTPA 101-115 solute carrier organic anion transporter family member 1B3 Homo sapiens 23-30 32064560-3 2020 Gadoxetic acid-enhanced MRI, an indirect molecular imaging method, reflects OATP1B3 expression in HCC. gadolinium ethoxybenzyl DTPA 0-14 solute carrier organic anion transporter family member 1B3 Homo sapiens 76-83 32410411-11 2020 CONCLUSION: The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI. gadolinium ethoxybenzyl DTPA 137-151 solute carrier organic anion transporter family member 1B3 Homo sapiens 33-40 32410411-11 2020 CONCLUSION: The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI. gadolinium ethoxybenzyl DTPA 137-151 solute carrier organic anion transporter family member 1B3 Homo sapiens 106-113 29709031-0 2018 Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin. gadolinium ethoxybenzyl DTPA 0-14 solute carrier organic anion transporter family member 1B3 Homo sapiens 222-229 26187715-0 2015 Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome. gadolinium ethoxybenzyl DTPA 20-31 solute carrier organic anion transporter family member 1B3 Homo sapiens 65-72 24946283-0 2014 OATP1B3 expression is strongly associated with Wnt/beta-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma. gadolinium ethoxybenzyl DTPA 109-123 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-7 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. gadolinium ethoxybenzyl DTPA 81-140 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-37 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. gadolinium ethoxybenzyl DTPA 81-140 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-46 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. gadolinium ethoxybenzyl DTPA 142-153 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-37 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. gadolinium ethoxybenzyl DTPA 142-153 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-46 24700365-2 2014 Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions with regard to vascularity and the activity of the organic anion transporter OATP1B3. gadolinium ethoxybenzyl DTPA 0-59 solute carrier organic anion transporter family member 1B3 Homo sapiens 250-257 24700365-2 2014 Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions with regard to vascularity and the activity of the organic anion transporter OATP1B3. gadolinium ethoxybenzyl DTPA 61-72 solute carrier organic anion transporter family member 1B3 Homo sapiens 250-257 20406852-4 2010 In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM). gadolinium ethoxybenzyl DTPA 23-34 solute carrier organic anion transporter family member 1B3 Homo sapiens 118-125 21628934-6 2011 Immunohistochemical analysis revealed a markedly reduced expression of organic anion transporter (OATP) 1B3 in this nodule, which implied decreased Gd-EOB-DTPA uptake by hepatocytes and accounted for the low signal intensity during the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI. gadolinium ethoxybenzyl DTPA 148-159 solute carrier organic anion transporter family member 1B3 Homo sapiens 71-107 21628934-6 2011 Immunohistochemical analysis revealed a markedly reduced expression of organic anion transporter (OATP) 1B3 in this nodule, which implied decreased Gd-EOB-DTPA uptake by hepatocytes and accounted for the low signal intensity during the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI. gadolinium ethoxybenzyl DTPA 259-270 solute carrier organic anion transporter family member 1B3 Homo sapiens 71-107 23903870-4 2014 Uptakes of Sonazoid and Gd-EOB-DTPA were assessed by Sonazoid enhancement index and EOB enhancement ratio in relation to immunohistochemistry of CD68 and organic anion transporting polypeptide 8 (OATP8), respectively. gadolinium ethoxybenzyl DTPA 24-35 solute carrier organic anion transporter family member 1B3 Homo sapiens 154-194 22771883-1 2012 PURPOSE: To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects. gadolinium ethoxybenzyl DTPA 162-176 solute carrier organic anion transporter family member 1B3 Homo sapiens 125-132 22771883-3 2012 Cellular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured by using stable transfected embryonic kidney HEK293 cells. gadolinium ethoxybenzyl DTPA 19-33 solute carrier organic anion transporter family member 1B3 Homo sapiens 49-56 22771883-10 2012 CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjects. gadolinium ethoxybenzyl DTPA 71-85 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-46 21626360-0 2011 The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging. gadolinium ethoxybenzyl DTPA 106-120 solute carrier organic anion transporter family member 1B3 Homo sapiens 23-28 21626360-1 2011 OBJECTIVES: To clarify the changes in organic anion-transporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis. gadolinium ethoxybenzyl DTPA 123-137 solute carrier organic anion transporter family member 1B3 Homo sapiens 80-85 21626360-8 2011 CONCLUSIONS: The immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis, which may explain the decrease in enhancement ratio on gadoxetic acid-enhanced MR imaging. gadolinium ethoxybenzyl DTPA 175-189 solute carrier organic anion transporter family member 1B3 Homo sapiens 51-56 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. gadolinium ethoxybenzyl DTPA 72-86 solute carrier organic anion transporter family member 1B3 Homo sapiens 155-160 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. gadolinium ethoxybenzyl DTPA 72-86 solute carrier organic anion transporter family member 1B3 Homo sapiens 217-222 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. gadolinium ethoxybenzyl DTPA 187-201 solute carrier organic anion transporter family member 1B3 Homo sapiens 155-160 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. gadolinium ethoxybenzyl DTPA 187-201 solute carrier organic anion transporter family member 1B3 Homo sapiens 217-222 20406852-9 2010 In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP. gadolinium ethoxybenzyl DTPA 15-26 solute carrier organic anion transporter family member 1B3 Homo sapiens 73-80 19404564-0 2009 Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. gadolinium ethoxybenzyl DTPA 43-54 solute carrier organic anion transporter family member 1B3 Homo sapiens 14-21 19404564-8 2009 HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001). gadolinium ethoxybenzyl DTPA 10-21 solute carrier organic anion transporter family member 1B3 Homo sapiens 43-50 19404564-8 2009 HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001). gadolinium ethoxybenzyl DTPA 10-21 solute carrier organic anion transporter family member 1B3 Homo sapiens 102-109 19404564-9 2009 CONCLUSIONS: Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production. gadolinium ethoxybenzyl DTPA 23-34 solute carrier organic anion transporter family member 1B3 Homo sapiens 73-80