PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28266528-2 2017 Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. gadolinium ethoxybenzyl DTPA 135-146 solute carrier organic anion transporter family member 1B1 Homo sapiens 11-18 34445497-6 2021 In the OATP1B1 transfected 293T transient expression model, both Gd-BOPTA and Gd-EOB-DTPA uptake were confirmed through 1.5 T MR imaging. gadolinium ethoxybenzyl DTPA 78-89 solute carrier organic anion transporter family member 1B1 Homo sapiens 7-14 29695578-0 2018 cDNA Microarray Analysis and Influx Transporter OATP1B1 in Liver Cells After Exposure to Gadoxetate Disodium, a Gadolinium-based Contrast Agent in MRI Liver Imaging. gadolinium ethoxybenzyl DTPA 89-108 solute carrier organic anion transporter family member 1B1 Homo sapiens 48-55 29695578-10 2018 Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression. gadolinium ethoxybenzyl DTPA 44-54 solute carrier organic anion transporter family member 1B1 Homo sapiens 77-118 29695578-10 2018 Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression. gadolinium ethoxybenzyl DTPA 44-54 solute carrier organic anion transporter family member 1B1 Homo sapiens 120-127 35552472-3 2022 Gadoxetic acid is also transported by OATP1B1/1B3, and we aimed to evaluate whether gadoxetic acid-enhanced magnetic resonance (MR) imaging was associated with glecaprevir trough concentrations (Ctrough). gadolinium ethoxybenzyl DTPA 0-14 solute carrier organic anion transporter family member 1B1 Homo sapiens 38-49 35552472-3 2022 Gadoxetic acid is also transported by OATP1B1/1B3, and we aimed to evaluate whether gadoxetic acid-enhanced magnetic resonance (MR) imaging was associated with glecaprevir trough concentrations (Ctrough). gadolinium ethoxybenzyl DTPA 84-98 solute carrier organic anion transporter family member 1B1 Homo sapiens 38-49 33084108-0 2021 Unusual Distribution Kinetics of Gadoxetate in Healthy Human Subjects Genotyped for OATP1B1: Application of Population Analysis and a Minimal Physiological-Based Pharmacokinetic Model. gadolinium ethoxybenzyl DTPA 33-43 solute carrier organic anion transporter family member 1B1 Homo sapiens 84-91 33084108-6 2021 In elucidating the impact of OATP1B1 genotype (*1a/*1a and *15/*15) on the pharmacokinetics of gadoxetate, we found that tissue uptake and back-transfer rates were significantly reduced, whereas the hepatic sinusoidal efflux rate was significantly increased in carriers of the *15/*15 haplotype compared with those of the *1a/*1a (wild type). gadolinium ethoxybenzyl DTPA 95-105 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-36 32458127-6 2020 Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes. gadolinium ethoxybenzyl DTPA 161-175 solute carrier organic anion transporter family member 1B1 Homo sapiens 106-117 29709031-0 2018 Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin. gadolinium ethoxybenzyl DTPA 0-14 solute carrier organic anion transporter family member 1B1 Homo sapiens 169-217 29709031-2 2018 Gadoxetic acid is also transported by OATP1B1/1B3. gadolinium ethoxybenzyl DTPA 0-14 solute carrier organic anion transporter family member 1B1 Homo sapiens 38-49 22771883-1 2012 PURPOSE: To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects. gadolinium ethoxybenzyl DTPA 162-176 solute carrier organic anion transporter family member 1B1 Homo sapiens 71-120 25985059-11 2015 The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP. gadolinium ethoxybenzyl DTPA 74-88 solute carrier organic anion transporter family member 1B1 Homo sapiens 14-21 22771883-3 2012 Cellular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured by using stable transfected embryonic kidney HEK293 cells. gadolinium ethoxybenzyl DTPA 19-33 solute carrier organic anion transporter family member 1B1 Homo sapiens 37-44 22771883-7 2012 Liver enhancement with gadoxetic acid was reduced in subjects with OATP1B1*1a/*5 compared with wild-type subjects and those with OATP1B1*1b/*1b (area under enhancement curve, 3-480 minutes in arbitrary units [au]; 20.7 au +- 6.85 vs 36.5 au +- 8.08 [P = .006] vs 34.6 au +- 8.92 [P = .026]). gadolinium ethoxybenzyl DTPA 23-37 solute carrier organic anion transporter family member 1B1 Homo sapiens 67-74 22771883-10 2012 CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjects. gadolinium ethoxybenzyl DTPA 71-85 solute carrier organic anion transporter family member 1B1 Homo sapiens 27-34 22771883-11 2012 Genetic polymorphisms of OATP1B1 are signal confounders in gadoxetic acid-enhanced liver MR imaging. gadolinium ethoxybenzyl DTPA 59-73 solute carrier organic anion transporter family member 1B1 Homo sapiens 25-32 21691816-1 2011 The organic anion transporter peptides (OATP) 1B1 and 1B3 are hepatocytic-specific transporters determinant for the uptake of the contrast media Gd-EOB-DTPA during magnetic resonance, but variably lost in hepatocellular carcinoma (HCC). gadolinium ethoxybenzyl DTPA 145-156 solute carrier organic anion transporter family member 1B1 Homo sapiens 4-57 22504332-3 2012 The hepatocyte uptake of Gd-EOB-DTPA mainly occurs via the organic anion transporter polypeptides OATP1B1 and B3 located at the sinusoidal membrane and biliary excretion via the multidrug resistance-associated proteins MRP2 at the canalicular membrane. gadolinium ethoxybenzyl DTPA 25-36 solute carrier organic anion transporter family member 1B1 Homo sapiens 98-105 22391331-8 2012 The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1. gadolinium ethoxybenzyl DTPA 57-67 solute carrier organic anion transporter family member 1B1 Homo sapiens 98-105 22391331-8 2012 The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1. gadolinium ethoxybenzyl DTPA 57-67 solute carrier organic anion transporter family member 1B1 Homo sapiens 361-368 20406852-4 2010 In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM). gadolinium ethoxybenzyl DTPA 23-34 solute carrier organic anion transporter family member 1B1 Homo sapiens 88-95 20406852-9 2010 In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP. gadolinium ethoxybenzyl DTPA 15-26 solute carrier organic anion transporter family member 1B1 Homo sapiens 64-71