PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27614128-0 2016 Pioglitazone inhibits EGFR/MDM2 signaling-mediated PPARgamma degradation. Pioglitazone 0-12 epidermal growth factor receptor Homo sapiens 22-26 8679718-0 1996 Pioglitazone attenuates the inhibitory effect of phorbol ester on epidermal growth factor receptor autophosphorylation and tyrosine kinase activity. Pioglitazone 0-12 epidermal growth factor receptor Homo sapiens 66-98 8679718-1 1996 A new anti-diabetic drug, pioglitazone, was tested as to whether it could ameliorate the decreased kinase activity of epidermal growth factor (EGF) receptor induced by phorbol ester (PMA) in A431 cells. Pioglitazone 26-38 epidermal growth factor receptor Homo sapiens 118-156 8679718-6 1996 These results suggest that pioglitazone may act as a specific antagonist to the inhibitory effect by protein kinase C on the EGF receptor tyrosine kinase. Pioglitazone 27-39 epidermal growth factor receptor Homo sapiens 125-137 27614128-5 2016 Therefore, our study revealed a novel mechanism that pioglitazone inhibited EGFR/MDM2-mediated cancer cell chemoresistance, which provides a novel strategy for cancer treatment. Pioglitazone 53-65 epidermal growth factor receptor Homo sapiens 76-80 23370527-8 2013 The PPARgamma and EGFR interaction was determined by chromatin immunoprecipitation assay, and the effect of pioglitazone on EGFR activation by luciferase assay. Pioglitazone 108-120 epidermal growth factor receptor Homo sapiens 124-128 23370527-9 2013 RESULTS: PTCs exposed to both high glucose and pioglitazone increased protein abundance of P-EGFR, NHE3, AQP1 and PPARgamma. Pioglitazone 47-59 epidermal growth factor receptor Homo sapiens 93-97 23370527-13 2013 Pioglitazone induced PPARgamma binding to the EGFR promoter and subsequent downstream activation. Pioglitazone 0-12 epidermal growth factor receptor Homo sapiens 46-50