PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28595081-0	2017	Pioglitazone attenuates lipopolysaccharide-induced depression-like behaviors, modulates NF-kappaB/IL-6/STAT3, CREB/BDNF pathways and central serotonergic neurotransmission in mice.	Pioglitazone	0-12	signal transducer and activator of transcription 3	Mus musculus	103-108	
31277592-0	2019	The PPARgamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3.	Pioglitazone	22-34	signal transducer and activator of transcription 3	Mus musculus	100-105	
31277592-9	2019	Pioglitazone inhibited renal mRNA expression of all the profibrotic effectors: type-III collagen, TGF-beta1, CTGF and TIMP-1, and alike transcription factors cFos/cJun and protein expression of EGR-1, and STAT3 protein phosphorylation.	Pioglitazone	0-12	signal transducer and activator of transcription 3	Mus musculus	205-210	
31277592-10	2019	CONCLUSIONS: Oral administration of PPARgamma agonist pioglitazone significantly reduces TGF-beta1-driven renal fibrosis, via the attenuation of EGR-1, STAT3 and AP-1.	Pioglitazone	54-66	signal transducer and activator of transcription 3	Mus musculus	152-157	
16328104-7	2006	The improvement of colitis by pioglitazone was associated with decreased colonic interleukin-6, and phospho-signal transducer and activator of transcription-3 levels.	Pioglitazone	30-42	signal transducer and activator of transcription 3	Mus musculus	108-158	
19925559-0	2010	Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis.	Pioglitazone	46-58	signal transducer and activator of transcription 3	Mus musculus	62-67	
19925559-5	2010	Immunoblot analysis delineated significant increases in nuclear p-STAT3 levels in non-treated ALS mice as compared with pioglitazone-treated ALS mice and non-treated and pioglitazone-treated control mice.	Pioglitazone	170-182	signal transducer and activator of transcription 3	Mus musculus	66-71	
19925559-8	2010	Moreover, it is likely that pioglitazone may exert inhibitory effects on STAT3-mediated proinflammtory mechanisms in this disease.	Pioglitazone	28-40	signal transducer and activator of transcription 3	Mus musculus	73-78	
28467929-6	2017	The PPARgamma agonist pioglitazone reverses PAH and inhibits the TGFbeta1-Stat3-FoxO1 axis in TGFbeta1-overexpressing mice.	Pioglitazone	22-34	signal transducer and activator of transcription 3	Mus musculus	74-79	
26868449-2	2016	The ability of either recombinant Interleukin-6 (rIL6) or pioglitazone to modulate MSC migration, essential for wound healing, by targeting the inflammation-modulated IL6/STAT3 signalling pathway was therefore investigated in bone marrow-derived MSCs from control (C57BL/6J) and pre-diabetic obese mice (B6.	Pioglitazone	58-70	signal transducer and activator of transcription 3	Mus musculus	171-176	
17327450-9	2007	Conversely, pioglitazone increased adiponectin secretion and STAT3 phosphorylation in fat tissue of db/db mice and in 3T3-L1 adipocytes.	Pioglitazone	12-24	signal transducer and activator of transcription 3	Mus musculus	61-66	
17327450-10	2007	These results suggest that pioglitazone exerts its effect to improve whole-body insulin sensitivity in part through the suppression of SOCS3, which is associated with the increase in STAT3 phosphorylation and adiponectin production in fat tissue.	Pioglitazone	27-39	signal transducer and activator of transcription 3	Mus musculus	183-188