PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24910998-0 2014 The natural chemopreventive agent sulforaphane inhibits STAT5 activity. sulforaphane 34-46 signal transducer and activator of transcription 5A Homo sapiens 56-61 24910998-4 2014 We now investigated whether the dietary chemopreventive agent sulforaphane, known for its activity as deacetylase inhibitor, might also inhibit STAT5 activity and thus could act as a chemopreventive agent in STAT5-associated cancers. sulforaphane 62-74 signal transducer and activator of transcription 5A Homo sapiens 144-149 24910998-4 2014 We now investigated whether the dietary chemopreventive agent sulforaphane, known for its activity as deacetylase inhibitor, might also inhibit STAT5 activity and thus could act as a chemopreventive agent in STAT5-associated cancers. sulforaphane 62-74 signal transducer and activator of transcription 5A Homo sapiens 208-213 24910998-5 2014 We describe here sulforaphane (SFN) as a novel STAT5 inhibitor. sulforaphane 17-29 signal transducer and activator of transcription 5A Homo sapiens 47-52 24910998-5 2014 We describe here sulforaphane (SFN) as a novel STAT5 inhibitor. sulforaphane 31-34 signal transducer and activator of transcription 5A Homo sapiens 47-52 24910998-6 2014 We showed that SFN, like the deacetylase inhibitor trichostatin A (TSA), can inhibit expression of STAT5 target genes in the B cell line Ba/F3, as well as in its transformed counterpart Ba/F3-1*6 and in the human leukemic cell line K562 both of which express a constitutively active form of STAT5. sulforaphane 15-18 signal transducer and activator of transcription 5A Homo sapiens 99-104 24910998-6 2014 We showed that SFN, like the deacetylase inhibitor trichostatin A (TSA), can inhibit expression of STAT5 target genes in the B cell line Ba/F3, as well as in its transformed counterpart Ba/F3-1*6 and in the human leukemic cell line K562 both of which express a constitutively active form of STAT5. sulforaphane 15-18 signal transducer and activator of transcription 5A Homo sapiens 291-296 24910998-9 2014 Altogether, our data revealed that the natural compound sulforaphane can inhibit STAT5 downstream activity, and as such represents an attractive cancer chemoprotective agent targeting the STAT5 signaling pathway. sulforaphane 56-68 signal transducer and activator of transcription 5A Homo sapiens 81-86 24910998-9 2014 Altogether, our data revealed that the natural compound sulforaphane can inhibit STAT5 downstream activity, and as such represents an attractive cancer chemoprotective agent targeting the STAT5 signaling pathway. sulforaphane 56-68 signal transducer and activator of transcription 5A Homo sapiens 188-193