PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23902242-5	2013	A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-kappaB, SHH, epithelial-mesenchymal transition and Wnt/beta-catenin pathways.	sulforaphane	40-52	sonic hedgehog signaling molecule	Homo sapiens	131-134	
23129257-10	2013	Since aberrant Shh signaling occurs in pancreatic tumorigenesis, therapeutics that target Shh pathway may improve the outcomes of patients with pancreatic cancer by targeting CSCs, thus suggesting the use of sulforaphane to further improve preventive and therapeutic approaches in patients with this devastating disease.	sulforaphane	208-220	sonic hedgehog signaling molecule	Homo sapiens	90-93	
23029396-0	2012	Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.	sulforaphane	83-95	sonic hedgehog signaling molecule	Homo sapiens	0-14	
23029396-9	2012	Interference of Shh-Gli signaling significantly blocked SFN-induced inhibitory effects demonstrating the requirement of an active pathway for the growth of pancreatic CSCs.	sulforaphane	56-59	sonic hedgehog signaling molecule	Homo sapiens	16-19	
23029396-13	2012	We propose that pancreatic cancer preventative effects of SFN may result from inhibition of the Shh pathway.	sulforaphane	58-61	sonic hedgehog signaling molecule	Homo sapiens	96-99	
34424425-0	2021	Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3.	sulforaphane	0-12	sonic hedgehog signaling molecule	Homo sapiens	87-101	
35157913-0	2022	Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway.	sulforaphane	0-12	sonic hedgehog signaling molecule	Homo sapiens	73-87	
29285189-0	2018	Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling.	sulforaphane	0-12	sonic hedgehog signaling molecule	Homo sapiens	87-101	
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	sonic hedgehog signaling molecule	Homo sapiens	54-57	
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	127-130	sonic hedgehog signaling molecule	Homo sapiens	192-195	
29285189-10	2018	The results of the present study demonstrated that SFN inhibits the proliferation of gefitinib-tolerant lung cancer cells via modulation of the SHH signaling pathway.	sulforaphane	51-54	sonic hedgehog signaling molecule	Homo sapiens	144-147