PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25070589-0	2015	Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1B	Homo sapiens	50-54	
25070589-4	2015	We herein provide the first evidence supporting the critical involvement of the SKP2-p27(KIP1) axis in sulforaphane-induced antiproliferation in various human colon adenocarcinoma cell lines.	sulforaphane	103-115	cyclin dependent kinase inhibitor 1B	Homo sapiens	89-93	
25070589-6	2015	Of note, sulforaphane-induced antiproliferation was accompanied with down-regulation of SKP2, leading to the stabilization and thus up-regulation of p27(KIP1).	sulforaphane	9-21	cyclin dependent kinase inhibitor 1B	Homo sapiens	153-157	
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	cyclin dependent kinase inhibitor 1B	Homo sapiens	155-159	
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	cyclin dependent kinase inhibitor 1B	Homo sapiens	275-279	
20944112-6	2010	In MDA-MB-231 cells, 30 muM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels.	sulforaphane	28-31	cyclin dependent kinase inhibitor 1B	Homo sapiens	106-113	
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	cyclin dependent kinase inhibitor 1B	Homo sapiens	47-51