PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26827637-0 2016 Sulforaphane exerts its anti-inflammatory effect against amyloid-beta peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages. sulforaphane 0-12 signal transducer and activator of transcription 1 Homo sapiens 82-88 26827637-4 2016 Subsequent mechanistic studies revealed that sulforaphane mitigated the activation of signal transducer and activator of transcription-1 induced by Abeta1-42 monomers. sulforaphane 45-57 signal transducer and activator of transcription 1 Homo sapiens 86-136 26827637-9 2016 These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells. sulforaphane 212-224 signal transducer and activator of transcription 1 Homo sapiens 28-78