PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28132875-2 2017 Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition). sulforaphane 53-65 histone deacetylase 9 Homo sapiens 112-131 34082508-1 2021 Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. sulforaphane 30-42 histone deacetylase 9 Homo sapiens 129-148 34082508-1 2021 Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. sulforaphane 30-42 histone deacetylase 9 Homo sapiens 150-154 34082508-1 2021 Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. sulforaphane 44-47 histone deacetylase 9 Homo sapiens 129-148 34082508-1 2021 Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. sulforaphane 44-47 histone deacetylase 9 Homo sapiens 150-154 31846091-0 2020 Histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human breast cancer cells. sulforaphane 85-97 histone deacetylase 9 Homo sapiens 0-19 31846091-3 2020 METHODS: This study employed a combinatorial chemopreventive strategy to investigate the impact of dietary histone deacetylase (HDAC) inhibitor, that is, sulforaphane on chromatin remodeling in BC. sulforaphane 154-166 histone deacetylase 9 Homo sapiens 107-126 31846091-3 2020 METHODS: This study employed a combinatorial chemopreventive strategy to investigate the impact of dietary histone deacetylase (HDAC) inhibitor, that is, sulforaphane on chromatin remodeling in BC. sulforaphane 154-166 histone deacetylase 9 Homo sapiens 128-132 31304933-2 2019 Schizophrenia patients are abnormal in oxidative stress, immune regulation, and anti-histone deacetylase (HDAC), while sulforaphane plays a role in anti-oxidative stress, anti-inflammation, and anti-HDAC. sulforaphane 119-131 histone deacetylase 9 Homo sapiens 199-203 30026053-0 2018 Relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors. sulforaphane 40-52 histone deacetylase 9 Homo sapiens 25-29 28176652-9 2018 CONCLUSION: Our studies suggest that the regulation of HDAC, hTERT and miR-21 is a promising approach for delaying and/or preventing CRC and may be accomplished via the consumption of SFN in cruciferous vegetables. sulforaphane 184-187 histone deacetylase 9 Homo sapiens 55-59 28132875-2 2017 Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition). sulforaphane 53-65 histone deacetylase 9 Homo sapiens 133-137 28132875-2 2017 Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition). sulforaphane 67-70 histone deacetylase 9 Homo sapiens 112-131 28132875-2 2017 Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition). sulforaphane 67-70 histone deacetylase 9 Homo sapiens 133-137 25307283-0 2015 The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. sulforaphane 14-26 histone deacetylase 9 Homo sapiens 30-49 27281367-7 2017 This article focuses on plant-derived HDAC inhibitor Sulforaphane (SFN) as a promising antipancreatic cancer agent. sulforaphane 53-65 histone deacetylase 9 Homo sapiens 38-42 27281367-7 2017 This article focuses on plant-derived HDAC inhibitor Sulforaphane (SFN) as a promising antipancreatic cancer agent. sulforaphane 67-70 histone deacetylase 9 Homo sapiens 38-42 25307283-1 2015 Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. sulforaphane 0-12 histone deacetylase 9 Homo sapiens 147-166 25307283-1 2015 Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. sulforaphane 0-12 histone deacetylase 9 Homo sapiens 168-172 25307283-3 2015 Significant inhibition of HDAC activity in HCT116 nuclear extracts required prolonged exposure to sulforaphane in the presence of serum. sulforaphane 98-110 histone deacetylase 9 Homo sapiens 26-30 25307283-5 2015 Both cell types displayed down-regulation of HDAC protein levels by sulforaphane treatment. sulforaphane 68-80 histone deacetylase 9 Homo sapiens 45-49 25307283-6 2015 Despite these reductions in HDAC family member protein levels, acetylation of marker proteins (acetylated Histone H3, H4, and tubulin) was decreased by sulforaphane treatment. sulforaphane 152-164 histone deacetylase 9 Homo sapiens 28-32 25307283-10 2015 In addition, our data suggest that keratinocytes are at least partially resistant to the nuclear HDAC inhibitory effects of sulforaphane, which is exhibited in HCT116 and other cells. sulforaphane 124-136 histone deacetylase 9 Homo sapiens 97-101 16280330-0 2006 Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. sulforaphane 0-12 histone deacetylase 9 Homo sapiens 22-41 19812222-0 2009 Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. sulforaphane 8-20 histone deacetylase 9 Homo sapiens 24-43 19812222-5 2009 We have previously found that sulforaphane (SFN), a compound found in cruciferous vegetables, inhibits HDAC activity in human colorectal and prostate cancer cells. sulforaphane 30-42 histone deacetylase 9 Homo sapiens 103-107 19812222-5 2009 We have previously found that sulforaphane (SFN), a compound found in cruciferous vegetables, inhibits HDAC activity in human colorectal and prostate cancer cells. sulforaphane 44-47 histone deacetylase 9 Homo sapiens 103-107 19812222-6 2009 Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, we previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention. sulforaphane 126-138 histone deacetylase 9 Homo sapiens 77-81 19812222-6 2009 Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, we previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention. sulforaphane 126-138 histone deacetylase 9 Homo sapiens 151-155 18373608-0 2008 The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. sulforaphane 42-54 histone deacetylase 9 Homo sapiens 12-31 18373608-2 2008 The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection. sulforaphane 50-62 histone deacetylase 9 Homo sapiens 12-31 18373608-2 2008 The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection. sulforaphane 50-62 histone deacetylase 9 Homo sapiens 33-37 18373608-2 2008 The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection. sulforaphane 64-67 histone deacetylase 9 Homo sapiens 12-31 18373608-2 2008 The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection. sulforaphane 64-67 histone deacetylase 9 Homo sapiens 33-37 18373608-11 2008 The data clearly demonstrate for the first time that the dietary HDAC inhibitor SFN is able to induce antimicrobial peptides in colonocytes. sulforaphane 80-83 histone deacetylase 9 Homo sapiens 65-69 26388957-1 2015 BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. sulforaphane 30-42 histone deacetylase 9 Homo sapiens 198-202 26388957-1 2015 BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. sulforaphane 44-47 histone deacetylase 9 Homo sapiens 198-202 17555985-4 2007 SFN also inhibited the growth of prostate cancer xenografts and spontaneous intestinal polyps in mouse models, with evidence for altered histone acetylation and HDAC activities in vivo. sulforaphane 0-3 histone deacetylase 9 Homo sapiens 161-165 16611031-8 2006 Interestingly, three dietary chemopreventive agents, butyrate, diallyl disulfide, and sulforaphane, also have HDAC inhibitory activity. sulforaphane 86-98 histone deacetylase 9 Homo sapiens 110-114 16280330-2 2006 We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (HDAC). sulforaphane 64-67 histone deacetylase 9 Homo sapiens 122-141 16280330-2 2006 We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (HDAC). sulforaphane 64-67 histone deacetylase 9 Homo sapiens 143-147 16280330-3 2006 Here, we show that addition of 15 microM SFN also inhibited HDAC activity by 40, 30 and 40% in BPH-1, LnCaP and PC-3 prostate epithelial cells, respectively. sulforaphane 41-44 histone deacetylase 9 Homo sapiens 60-64 16280330-4 2006 The inhibition of HDAC was accompanied by a 50-100% increase in acetylated histones in all three prostate cell lines, and in BPH-1 cells treated with SFN there was enhanced interaction of acetylated histone H4 with the promoter region of the P21 gene and the bax gene. sulforaphane 150-153 histone deacetylase 9 Homo sapiens 18-22 15313918-0 2004 A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. sulforaphane 40-52 histone deacetylase 9 Homo sapiens 68-87 16407454-0 2006 Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. sulforaphane 0-12 histone deacetylase 9 Homo sapiens 22-41 16407454-3 2006 In mice treated with a single oral dose of 10 mumol SFN, there was significant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer-term treatment with SFN in the diet resulted in levels of acetylated histones and p21(WAF1) in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls. sulforaphane 52-55 histone deacetylase 9 Homo sapiens 93-97 16407454-5 2006 These results provide the first evidence for HDAC inhibition by SFN in vivo and imply that such a mechanism might contribute to the cancer chemoprotective and therapeutic effects of SFN, alone or in combination with other HDAC inhibitors currently undergoing clinical trials. sulforaphane 64-67 histone deacetylase 9 Homo sapiens 45-49 16407454-5 2006 These results provide the first evidence for HDAC inhibition by SFN in vivo and imply that such a mechanism might contribute to the cancer chemoprotective and therapeutic effects of SFN, alone or in combination with other HDAC inhibitors currently undergoing clinical trials. sulforaphane 182-185 histone deacetylase 9 Homo sapiens 45-49 15313918-3 2004 We tested the hypothesis that SFN acts as an inhibitor of histone deacetylase (HDAC). sulforaphane 30-33 histone deacetylase 9 Homo sapiens 58-77 15313918-3 2004 We tested the hypothesis that SFN acts as an inhibitor of histone deacetylase (HDAC). sulforaphane 30-33 histone deacetylase 9 Homo sapiens 79-83 15313918-8 2004 Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter. sulforaphane 95-98 histone deacetylase 9 Homo sapiens 167-171