PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27470577-8	2016	These findings suggest that Keap1-Nrf2 system plays a key role in depression and that dietary intake of SFN-rich food during juvenile stages and adolescence can confer stress resilience in adulthood.	sulforaphane	104-107	kelch-like ECH-associated protein 1	Mus musculus	28-33	
34271100-0	2021	Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway.	sulforaphane	29-41	kelch-like ECH-associated protein 1	Mus musculus	91-96	
35041848-7	2022	Interestingly, both pretreatment and posttreatment with SFN significantly improved the abnormal behaviors of mice in the MWMT, in parallel with the up-regulated levels of Keap1-Nrf2 signaling in the mPFC, hippocampus and liver.	sulforaphane	56-59	kelch-like ECH-associated protein 1	Mus musculus	171-176	
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	9-21	kelch-like ECH-associated protein 1	Mus musculus	173-178	
26096705-0	2016	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-kappaB Pathways.	sulforaphane	0-12	kelch-like ECH-associated protein 1	Mus musculus	91-96	
26096705-9	2016	Our findings suggest that SFN may effectively attenuate 3-NP-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-kappaB pathways and that SFN has a wide therapeutic time-window for HD-like symptoms.	sulforaphane	26-29	kelch-like ECH-associated protein 1	Mus musculus	105-110	
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	23-25	kelch-like ECH-associated protein 1	Mus musculus	173-178	
22180572-4	2012	Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications.	sulforaphane	59-62	kelch-like ECH-associated protein 1	Mus musculus	114-119	
17015256-5	2006	Sulforaphane induces via activation of the Nrf2/Keap1 system phase 2 enzymes that protect against carcinogens and oxidants.	sulforaphane	0-12	kelch-like ECH-associated protein 1	Mus musculus	48-53	
20439747-2	2010	The mechanism of action of sulforaphane is believed to involve modifications of critical cysteine residues of Keap1, which lead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.	sulforaphane	27-39	kelch-like ECH-associated protein 1	Mus musculus	110-115	
20439747-3	2010	However, the dithiocarbamate functional group formed by a reversible reaction between isothiocyanate of sulforaphane and sulfhydryl nucleophiles of Keap1 is kinetically labile, and such modification in intact cells has not yet been demonstrated.	sulforaphane	104-116	kelch-like ECH-associated protein 1	Mus musculus	148-153	
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	kelch-like ECH-associated protein 1	Mus musculus	46-51	
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	kelch-like ECH-associated protein 1	Mus musculus	114-119