PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31884211-5	2020	The results showed that SFN prevented Cr-induced oxidative stress, histopathological lesions, inflammation, apoptosis, and changes in protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3beta) levels in vivo and in vitro.	sulforaphane	24-27	AKT serine/threonine kinase 1	Rattus norvegicus	152-155	
31884211-0	2020	Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3beta/Fyn pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	81-84	
31884211-8	2020	Collectively, this study demonstrates that SFN prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3beta/Fyn signaling pathway.	sulforaphane	43-46	AKT serine/threonine kinase 1	Rattus norvegicus	179-182	
31217757-0	2019	Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	76-79	
31217757-13	2019	The underlying mechanism revealed that sulforaphane attenuated EM in the rat model by inhibition of PI3K/Akt signaling pathway.	sulforaphane	39-51	AKT serine/threonine kinase 1	Rattus norvegicus	105-108	
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	AKT serine/threonine kinase 1	Rattus norvegicus	71-74	
28110122-8	2017	Otherwise, ERK1/2 and Akt signaling pathways seem to be involved, as the presence of specific inhibitors of these kinases reduced the protective effect of sulforaphane in the presence of 17beta-estradiol.	sulforaphane	155-167	AKT serine/threonine kinase 1	Rattus norvegicus	22-25	
30835071-0	2019	Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	80-83	
30835071-3	2019	The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling.	sulforaphane	57-69	AKT serine/threonine kinase 1	Rattus norvegicus	122-125	
30835071-3	2019	The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling.	sulforaphane	71-74	AKT serine/threonine kinase 1	Rattus norvegicus	122-125	
30835071-8	2019	Pretreatment with SFN significantly (P < 0.05) attenuated renal ROS, OHdG, lipid peroxidation, and DNA damage, and increased phase II antioxidants via PI3K/Akt-mediated Nrf2 activation in renal tissue.	sulforaphane	18-21	AKT serine/threonine kinase 1	Rattus norvegicus	159-162	
30835071-9	2019	These results show that dietary supplementation with SFN protects against Ar-induced nephrotoxicity via the PI3K/Akt-mediated Nrf2 signaling pathway in the rat kidney.	sulforaphane	53-56	AKT serine/threonine kinase 1	Rattus norvegicus	113-116	
31001960-0	2019	Sulforaphane Potentially Ameliorates Arsenic Induced Hepatotoxicity in Albino Wistar Rats: Implication of PI3K/Akt/Nrf2 Signaling Pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	111-114	
31001960-3	2019	The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway.	sulforaphane	69-81	AKT serine/threonine kinase 1	Rattus norvegicus	162-165	
31001960-3	2019	The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway.	sulforaphane	83-86	AKT serine/threonine kinase 1	Rattus norvegicus	162-165	
23784363-10	2014	CONCLUSION: Based on our results, sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-kappaB.	sulforaphane	34-46	AKT serine/threonine kinase 1	Rattus norvegicus	181-184	
22417554-0	2011	Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway.	sulforaphane	36-48	AKT serine/threonine kinase 1	Rattus norvegicus	141-144