PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27553905-6	2016	Moreover, sulforaphane treatment significantly attenuated rotenone-inhibited mTOR-mediated p70S6K and 4E-BP1 signalling pathway, as well as neuronal apoptosis.	sulforaphane	10-22	ribosomal protein S6 kinase B1	Homo sapiens	91-97	
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	ribosomal protein S6 kinase B1	Homo sapiens	249-255	
25169428-3	2014	In addition, we observed that sulforaphane suppression of TPA-induced S6K1 and ERK1/2 activation played a critical role in attenuating PDCD4 poly-ubiquitination and Pdcd4 mRNA downregulation.	sulforaphane	30-42	ribosomal protein S6 kinase B1	Homo sapiens	70-74	
23389114-5	2013	Cell viability and ultrastructure, protein synthesis, autophagy induction and phosphorylation status of Akt and S6K1 kinases upon SFN treatment were determined.	sulforaphane	130-133	ribosomal protein S6 kinase B1	Homo sapiens	112-116	
23389114-9	2013	CONCLUSION: These results indicate that SFN is a potent inhibitor of the viability of breast cancer cells representing different activity of the ErbB2/ER-PI3K-Akt-mTOR-S6K1 [corrected] pro-survival pathway and suggest that it targets downstream elements of the pathway.	sulforaphane	40-43	ribosomal protein S6 kinase B1	Homo sapiens	168-172	
23389114-3	2013	Since epidemiologic as well as rodent tumor studies indicate that sulforaphane (SFN), a constituent of many edible cruciferous vegetables, might be a potent inhibitor of mammary carcinogenesis, we analyzed the response of four breast cancer cell lines representing different abnormalities in ErbB2/ER-PI3K-Akt-mTOR-S6K1[corrected] signaling pathway to this compound.	sulforaphane	66-78	ribosomal protein S6 kinase B1	Homo sapiens	315-319	
34731371-9	2022	The mechanism was that PP242 abrogated the promoting effects of SFN on p-p70S6K (Thr389) and p-Akt (Ser473) in ESCC.	sulforaphane	64-67	ribosomal protein S6 kinase B1	Homo sapiens	73-79