PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14514658-2 2004 Here, we report that SFN inhibited proliferation of cultured PC-3 human prostate cancer cells by inducing apoptosis that was characterized by appearance of cells with sub-G0/G1 DNA content, formation of cytoplasmic histone associated DNA fragments and cleavage of poly(ADP-ribose)polymerase (PARP). sulforaphane 21-24 poly(ADP-ribose) polymerase 1 Homo sapiens 264-290 14514658-2 2004 Here, we report that SFN inhibited proliferation of cultured PC-3 human prostate cancer cells by inducing apoptosis that was characterized by appearance of cells with sub-G0/G1 DNA content, formation of cytoplasmic histone associated DNA fragments and cleavage of poly(ADP-ribose)polymerase (PARP). sulforaphane 21-24 poly(ADP-ribose) polymerase 1 Homo sapiens 292-296 34982643-0 2021 Sulforaphane ameliorates amyloid-beta-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells. sulforaphane 0-12 poly(ADP-ribose) polymerase 1 Homo sapiens 85-90 34982643-7 2021 Sulforaphane also mitigated the injury due to oligomeric amyloid-beta1-42 through a mechanism involving inactivation of the PARP1/SIRT1 pathway. sulforaphane 0-12 poly(ADP-ribose) polymerase 1 Homo sapiens 124-129 34982643-9 2021 Moreover, sulforaphane can induce cell viability and SIRT1 expression, but reduce cell apoptosis, the activity of caspase-3 or -9, and PARP1 expression in oAbeta1-42-treated cells. sulforaphane 10-22 poly(ADP-ribose) polymerase 1 Homo sapiens 135-140 34982643-11 2021 In summary, sulforaphane reduces the inflammatory injury induced by oAbeta1-42 in ARPE-19 cell by inactivating the PARP1/SIRT1 pathway. sulforaphane 12-24 poly(ADP-ribose) polymerase 1 Homo sapiens 115-120 26310710-0 2015 Sulforaphane inhibits damage-induced poly (ADP-ribosyl)ation via direct interaction of its cellular metabolites with PARP-1. sulforaphane 0-12 poly(ADP-ribose) polymerase 1 Homo sapiens 117-123 26310710-7 2015 Interestingly, this sulforaphane metabolite-induced PARP-1 inhibition was prevented by thiol compounds. sulforaphane 20-32 poly(ADP-ribose) polymerase 1 Homo sapiens 52-58 26310710-8 2015 PARP-1 is a stimulating factor for DNA SSBR-rate and we further demonstrated that 25 muM sulforaphane also delayed the rejoining of H2 O2 -induced DNA strand breaks, although this might be partly due to increased lesion frequencies. sulforaphane 89-101 poly(ADP-ribose) polymerase 1 Homo sapiens 0-6 26296464-5 2015 Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio. sulforaphane 31-34 poly(ADP-ribose) polymerase 1 Homo sapiens 137-163 26296464-5 2015 Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio. sulforaphane 31-34 poly(ADP-ribose) polymerase 1 Homo sapiens 165-169 24296129-4 2014 Sulforaphane-induced apoptosis was associated with the activation of caspase-8 and -9, the initiators caspases of the extrinsic and intrinsic apoptotic pathways, respectively, and activation of effector caspase-3 and cleavage of poly (ADP-ribose) polymerase. sulforaphane 0-12 poly(ADP-ribose) polymerase 1 Homo sapiens 229-257 23404329-3 2013 Results demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose) polymerase (PARP) proteins. sulforaphane 83-86 poly(ADP-ribose) polymerase 1 Homo sapiens 281-320 23404329-3 2013 Results demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose) polymerase (PARP) proteins. sulforaphane 83-86 poly(ADP-ribose) polymerase 1 Homo sapiens 322-326 21720717-7 2011 Sulforaphane treatment also resulted in apoptosis as evidenced by an increase in annexin V+/propidium iodide- (V+/PI-) cells, the cleavage of 116-kDa poly (ADP-ribose) polymerase (PARP) and ICAD and oligonucleosomal DNA fragmentation. sulforaphane 0-12 poly(ADP-ribose) polymerase 1 Homo sapiens 180-184 20944112-10 2010 Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim). sulforaphane 81-84 poly(ADP-ribose) polymerase 1 Homo sapiens 208-243 20196847-8 2010 Cells treated with cytotoxic concentrations of SFN have reduced cell migration and increased apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP). sulforaphane 47-50 poly(ADP-ribose) polymerase 1 Homo sapiens 165-210 20196847-8 2010 Cells treated with cytotoxic concentrations of SFN have reduced cell migration and increased apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP). sulforaphane 47-50 poly(ADP-ribose) polymerase 1 Homo sapiens 212-216 17549366-6 2007 SFN-induced apoptosis was associated with the proteolytic activation of caspase-3, and the degradation/cleavage of poly (ADP-ribose) polymerase and the beta-catenin protein. sulforaphane 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 115-143 17339367-4 2007 Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage. sulforaphane 27-39 poly(ADP-ribose) polymerase 1 Homo sapiens 174-201 17339367-4 2007 Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage. sulforaphane 27-39 poly(ADP-ribose) polymerase 1 Homo sapiens 408-435 17237292-8 2007 This inhibitory effect of sulforaphane leads to a potent induction of apoptosis in all three cell lines, along with the cleavage of poly(ADP)ribose polymerase. sulforaphane 26-38 poly(ADP-ribose) polymerase 1 Homo sapiens 132-158 16500682-6 2006 Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3"-diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379.2 cell lines, suggestive of a p53-independent mechanism of apoptosis induction. sulforaphane 15-27 poly(ADP-ribose) polymerase 1 Homo sapiens 136-140 16500682-9 2006 Of note is that for sulforaphane only, ratios of pro- to anti-apoptotic Bcl-2 family protein levels directly correlated with apoptosis induction measured by PARP cleavage. sulforaphane 20-32 poly(ADP-ribose) polymerase 1 Homo sapiens 157-161 16033772-6 2005 At relatively high concentration (30-100 microM), sulforaphane is a cell growth modulator, as it induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase 3 activity, according to the appearance of the caspase 3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase in a time-dependent manner. sulforaphane 50-62 poly(ADP-ribose) polymerase 1 Homo sapiens 324-352