PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31931639-4	2020	Dioscin (20, 40, and 80 mg/kg) was administered intragastrically once daily for seven consecutive days prior to LPS challenge.Results:Our data revealed that dioscin significantly suppressed LPS-induced lung pathological changes, pulmonary capillary permeability, pulmonary edema, inflammatory cell infiltration, myeloperoxidase (MPO) activity, and cytokine production, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and keratinocyte chemoattractant (KC).	dioscin	157-164	interleukin 6	Homo sapiens	414-432	
32841225-7	2020	Dioscin suppressed TLR4/NF-0kappaB signaling, and attenuated the level of inflammatory mediators (IL-6, TNF-alpha) in IL-1ss-stimulated human NP cells.	dioscin	0-7	interleukin 6	Homo sapiens	98-102	
32792945-5	2020	We performed in vitro studies using androgen-sensitive (LNCaP) and androgen-independent (LNCaP -C81) cells to investigate the anticancer effects and possible mechanisms of dioscin after administering interleukin-6 (IL-6) and dihydrotestosterone (DHT).	dioscin	172-179	interleukin 6	Homo sapiens	200-213	
31933895-9	2019	Additionally, dioscin downregulated interleukin-6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha).	dioscin	14-21	interleukin 6	Homo sapiens	36-49	
31933895-9	2019	Additionally, dioscin downregulated interleukin-6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha).	dioscin	14-21	interleukin 6	Homo sapiens	51-55	
27317992-4	2016	Mechanism study showed that dioscin significantly decreased the expression levels of IL-1beta, IL-6, TNF-alpha, IkappaBalpha, p50 and p65 through regulating TLR4/MyD88 pathway to rehabilitate inflammation.	dioscin	28-35	interleukin 6	Homo sapiens	95-99	
29197622-4	2018	Mechanistic study showed that dioscin significantly up-regulated the expression levels of Sirt3, SOD2, and then suppressed inflammation by decreasing the expression levels of NF-kB, HMGB1, c-Jun, c-Fos, COX2, TNF-alpha, IL-1beta and IL-6.	dioscin	30-37	interleukin 6	Homo sapiens	233-237	
28377715-6	2017	Mechanistically, dioscin significantly decreased the protein levels of TLR4, MyD88, TRAF6, TKB1, TRAF3, phosphorylation levels of PI3K, Akt, IkappaBalpha, NF-kappaB, and the mRNA levels of IL-1beta, IL-6, and TNF-alpha against oxidative stress and inflammation (p < 0.05).	dioscin	17-24	interleukin 6	Homo sapiens	199-203	
26655640-3	2015	Our results showed that dioscin significantly attenuated hepatic stellate cells (HSCs) activation, improved collagen accumulation, and attenuated inflammation through down-regulating the levels of myeloid differentiation factor 88 (MyD88), nuclear factor kappaB (NF-kappaB), interleukin (IL)-1, IL-6 and tumour necrosis factor-alpha by decreasing Toll-like receptor (TLR)4 expression both in vivo and in vitro.	dioscin	24-31	interleukin 6	Homo sapiens	295-332