PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34262136-10	2022	Furthermore, we demonstrated that diosmetin markedly increased the expression of Nrf2 and HO-1 and reduced the ratio of acetylated NF-kappaB and NF-kappaB by activating the circ-Sirt1/Sirt1 axis, which inhibited oxidative stress and inflammation in vivo and in vitro.	diosmetin	34-43	heme oxygenase 1	Mus musculus	90-94	
28624062-13	2017	CONCLUSIONS: The renoprotective effects of diosmetin involved suppression of the nuclear factor-kappaB and mitochondrial apoptosis pathways, as well as activation of the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.	diosmetin	43-52	heme oxygenase 1	Mus musculus	214-230	
28365974-8	2018	Furthermore, diosmetin significantly increased the expression of Nrf2 along with its target gene HO-1 and blocked the activation of NLRP3 inflammasome in the lung tissues, which might be central to the protective effects of diosmetin.	diosmetin	13-22	heme oxygenase 1	Mus musculus	97-101	
28365974-8	2018	Furthermore, diosmetin significantly increased the expression of Nrf2 along with its target gene HO-1 and blocked the activation of NLRP3 inflammasome in the lung tissues, which might be central to the protective effects of diosmetin.	diosmetin	224-233	heme oxygenase 1	Mus musculus	97-101	
28365974-9	2018	Further supporting these results, in vitro experiments also showed that diosmetin activated Nrf2 and HO-1, as well as inhibited the NLRP3 inflammasome in both RAW264.7 and A549 cells.	diosmetin	72-81	heme oxygenase 1	Mus musculus	101-105