PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27678303-4 2016 Erianin inhibited HG-induced vascular endothelial growth factor (VEGF) expression, hypoxia-inducible factor 1-alpha (HIF-1alpha) translocation into nucleus and ERK1/2 activation in RF/6A and microglia BV-2 cells. Erianin 0-7 hypoxia inducible factor 1 subunit alpha Macaca mulatta 83-115 27678303-4 2016 Erianin inhibited HG-induced vascular endothelial growth factor (VEGF) expression, hypoxia-inducible factor 1-alpha (HIF-1alpha) translocation into nucleus and ERK1/2 activation in RF/6A and microglia BV-2 cells. Erianin 0-7 hypoxia inducible factor 1 subunit alpha Macaca mulatta 117-127 27678303-8 2016 In conclusion, our results demonstrate that erianin inhibits retinal neoangiogenesis by abrogating HG-induced VEGF expression by blocking ERK1/2-mediated HIF-1alpha activation in retinal endothelial and microglial cells, and further suppressing VEGF-induced activation of VEGFR2 and its downstream signals in retinal endothelial cells. Erianin 44-51 hypoxia inducible factor 1 subunit alpha Macaca mulatta 154-164