PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17958337-3 2007 This study was designed to assess whether udenafil, a substrate of CYP3A4, is also a P-glycoprotein substrate. udenafil 42-50 ATP binding cassette subfamily B member 1 Homo sapiens 85-99 17958337-4 2007 Udenafil stimulated P-glycoprotein ATPase activity, a putative measure of P-glycoprotein affinity, although with lower affinity than a proven substrate, verapamil. udenafil 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 20-34 17958337-4 2007 Udenafil stimulated P-glycoprotein ATPase activity, a putative measure of P-glycoprotein affinity, although with lower affinity than a proven substrate, verapamil. udenafil 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 74-88 17958337-6 2007 P-glycoprotein inhibitors such as cyclosporine, tariquidar and verapamil significantly increased the influx of udenafil and decreased the efflux of udenafil. udenafil 111-119 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 17958337-6 2007 P-glycoprotein inhibitors such as cyclosporine, tariquidar and verapamil significantly increased the influx of udenafil and decreased the efflux of udenafil. udenafil 148-156 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 17958337-7 2007 These results indicate that udenafil is a substrate for P-glycoprotein. udenafil 28-36 ATP binding cassette subfamily B member 1 Homo sapiens 56-70 17958337-8 2007 The low bioavailability, variable absorption and drug-drug interactions of udenafil may be related to the variability of CYP3A4 and P-glycoprotein expression and to possible CYP3A4 and P-glycoprotein interactions. udenafil 75-83 ATP binding cassette subfamily B member 1 Homo sapiens 132-146 17958337-8 2007 The low bioavailability, variable absorption and drug-drug interactions of udenafil may be related to the variability of CYP3A4 and P-glycoprotein expression and to possible CYP3A4 and P-glycoprotein interactions. udenafil 75-83 ATP binding cassette subfamily B member 1 Homo sapiens 185-199