PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23874979-4 2013 Relative to controls, U0126-treated cells showed constitutive decreases in phosphorylation through a T cell receptor stimulation time course on tyrosine residues found on upstream signaling proteins (CD3 chains, Lck, ZAP-70), as well as downstream signaling proteins (VAV1, PLCgamma1, Itk, NCK1). U 0126 22-27 phospholipase C gamma 1 Homo sapiens 274-283 11562428-9 2001 Furthermore, PD-98059 and U0126, two MAPK inhibitors, blocked PLC-gamma 1-induced expression of MDR1. U 0126 26-31 phospholipase C gamma 1 Homo sapiens 62-73 20889506-8 2010 In addition, we found that inhibition of ERK1/2 phosphorylation by U0126 resulted in a decreased phosphorylation of PLCgamma1, suggesting a feedback loop between ERK1/2 and PLCgamma1. U 0126 67-72 phospholipase C gamma 1 Homo sapiens 116-125 20889506-8 2010 In addition, we found that inhibition of ERK1/2 phosphorylation by U0126 resulted in a decreased phosphorylation of PLCgamma1, suggesting a feedback loop between ERK1/2 and PLCgamma1. U 0126 67-72 phospholipase C gamma 1 Homo sapiens 173-182