PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30458987-8 2018 Finally, exosomes enriched with miR-214 antagomir was further confirmed to reverse gefitinib resistance in vivo. Gefitinib 83-92 microRNA 214 Homo sapiens 32-39 22502680-8 2012 Knockdown of miR-214 altered the expression of PTEN and p-AKT and re-sensitized HCC827/GR to gefitinib. Gefitinib 93-102 microRNA 214 Homo sapiens 13-20 22502680-9 2012 Taken together, miR-214 may regulate the acquired resistance to gefitinib in HCC827 via PTEN/AKT signaling pathway. Gefitinib 64-73 microRNA 214 Homo sapiens 16-23 30458987-0 2018 Exosomal transfer of miR-214 mediates gefitinib resistance in non-small cell lung cancer. Gefitinib 38-47 microRNA 214 Homo sapiens 21-28 30458987-6 2018 MiRNA-214 was upregulated in gefitinib resistant PC-9GR cells and its derived exosomes by qPCR analysis. Gefitinib 29-38 microRNA 214 Homo sapiens 0-9 30458987-7 2018 Inhibition of exosomal miR-214 with antagomir reversed gefitinib resistance conferred by PC-9GR-derived exosomes in vitro, which was confirmed by flow cytometry analysis and westernblot of apoptotic protein (caspase-3, caspase-3 cleaved, bax) and anti-apoptotic protein (bcl-2). Gefitinib 55-64 microRNA 214 Homo sapiens 23-30 30458987-9 2018 Our results are the first to show that exosomes derived from gefitinib-resistant PC-9GR cells could transfer resistance to its recipient sensitive PC-9 cells, which might be mediated by exosomal transfer of miR-214. Gefitinib 61-70 microRNA 214 Homo sapiens 207-214