PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21981383-7	2011	There is an increased expression of tyrosinase related protein-1 involved in eumelanin synthesis.	eumelanin	77-86	tyrosinase related protein 1	Homo sapiens	36-64	
19449448-3	2009	Enzymatic components of melanosomes include tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase, which depend on the functions of OA1, P, MATP, ATP7A, and BLOC-1 to synthesize eumelanins and pheomelanins.	eumelanin	193-203	tyrosinase related protein 1	Homo sapiens	56-112	
8875952-10	1996	The mechanisms governing pheomelanin to eumelanin balance are dependent on L-cysteine, glutathione, and tyrosinase-related protein-1 expression, but none of these factors alone appears to be dominant in directing the synthesis of a particular type of melanin.	eumelanin	40-49	tyrosinase related protein 1	Homo sapiens	104-132	
15265682-7	2004	In cells expressing both TYR and TYRP1 or TYR and DCT, the total amount of melanin and/or eumelanin increased substantially more than that in cells expressing TYR alone.	eumelanin	90-99	tyrosinase related protein 1	Homo sapiens	33-38	
11775055-1	2001	Tyrosinase-related protein 1 (Tyrp1) is a melanocyte-specific gene product involved in eumelanin synthesis.	eumelanin	87-96	tyrosinase related protein 1	Homo sapiens	0-28	
11775055-1	2001	Tyrosinase-related protein 1 (Tyrp1) is a melanocyte-specific gene product involved in eumelanin synthesis.	eumelanin	87-96	tyrosinase related protein 1	Homo sapiens	30-35	
11775055-5	2001	There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, Tyrp1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity.	eumelanin	73-82	tyrosinase related protein 1	Homo sapiens	94-99	
7761345-6	1994	This multisequential step occurs not only by the induction of Ty synthesis but also by the induction of other regulatory proteins and factors such as dopachrome tautomerase, DHICA-oxidase, catalase, Ty-glycosylation in GERL, and Ty-transfer by coated vesicles to newly assigned melanogenic vacuoles in which not only eumelanin but also rather pronounced concomitant pheomelanin formation is seen.	eumelanin	317-326	tyrosinase related protein 1	Homo sapiens	174-187	
23862152-3	2013	Tyrp1 is involved in maintaining the stability of tyrosinase protein and modulating its catalytic activity in eumelanin synthesis.	eumelanin	110-119	tyrosinase related protein 1	Homo sapiens	0-5	
8348959-3	1993	In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.	eumelanin	62-71	tyrosinase related protein 1	Homo sapiens	12-17	
8348959-3	1993	In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.	eumelanin	112-121	tyrosinase related protein 1	Homo sapiens	12-17	
8348959-3	1993	In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.	eumelanin	112-121	tyrosinase related protein 1	Homo sapiens	99-104	
34638544-2	2021	Tyrosinase-related protein 1 (Tyrp1) is involved in eumelanin synthesis, catalyzing the oxidation of 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA) to 5,6-indolequinone-2-carboxylic acid (IQCA).	eumelanin	52-61	tyrosinase related protein 1	Homo sapiens	0-28	
34638544-2	2021	Tyrosinase-related protein 1 (Tyrp1) is involved in eumelanin synthesis, catalyzing the oxidation of 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA) to 5,6-indolequinone-2-carboxylic acid (IQCA).	eumelanin	52-61	tyrosinase related protein 1	Homo sapiens	30-35	
34638544-2	2021	Tyrosinase-related protein 1 (Tyrp1) is involved in eumelanin synthesis, catalyzing the oxidation of 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA) to 5,6-indolequinone-2-carboxylic acid (IQCA).	eumelanin	52-61	tyrosinase related protein 1	Homo sapiens	101-146	
33305505-4	2021	In this review, we focused on one factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene involved in the eumelanin synthesis via TYRP1 protein.	eumelanin	120-129	tyrosinase related protein 1	Homo sapiens	62-90	
33305505-4	2021	In this review, we focused on one factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene involved in the eumelanin synthesis via TYRP1 protein.	eumelanin	120-129	tyrosinase related protein 1	Homo sapiens	92-97	
33305505-4	2021	In this review, we focused on one factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene involved in the eumelanin synthesis via TYRP1 protein.	eumelanin	120-129	tyrosinase related protein 1	Homo sapiens	144-149	
27476599-7	2016	Plumage color was more polygenic than migratory orientation but showed strong associations on the Z chromosome that included SNPs linked to TYRP1, a gene involved in the production of eumelanin.	eumelanin	184-193	tyrosinase related protein 1	Homo sapiens	140-145