PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34439449-8 2021 Experiments using mushroom TYR suggest that L-cysteinamide at certain concentrations can inhibit eumelanin synthesis through a dual mechanism by inhibiting TYR-catalyzed dopaquinone synthesis and by diverting the synthesized dopaquinone to the formation of DOPA-cysteinamide conjugates rather than dopachrome. eumelanin 97-106 tyrosinase Homo sapiens 27-30 32664213-7 2020 The psi-PDA deposition by tyrosinase-catalyzed tyramine oxidation is thus proposed as a controllable and low-waste technology for selective surface functionalization and coating or for clean eumelanin particle production. eumelanin 191-200 tyrosinase Homo sapiens 26-36 25026474-3 2014 Tyrosinase is the critical enzyme in the biosynthesis of both brown/black eumelanin and yellow/red pheomelanin. eumelanin 74-83 tyrosinase Homo sapiens 0-10 18492181-4 2005 Proposed mechanisms of action include: (a) direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme; (b) mediating the switch mechanism from eumelanin to phaeomelanin production; (c) quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation; and d) modulation of depigmenting abilities of melanocytotoxic agents. eumelanin 193-202 tyrosinase Homo sapiens 77-87 15265682-7 2004 In cells expressing both TYR and TYRP1 or TYR and DCT, the total amount of melanin and/or eumelanin increased substantially more than that in cells expressing TYR alone. eumelanin 90-99 tyrosinase Homo sapiens 25-28 15265682-7 2004 In cells expressing both TYR and TYRP1 or TYR and DCT, the total amount of melanin and/or eumelanin increased substantially more than that in cells expressing TYR alone. eumelanin 90-99 tyrosinase Homo sapiens 33-36 15265682-7 2004 In cells expressing both TYR and TYRP1 or TYR and DCT, the total amount of melanin and/or eumelanin increased substantially more than that in cells expressing TYR alone. eumelanin 90-99 tyrosinase Homo sapiens 33-36 1655007-0 1991 Tyrosinase expression and its relationship to eumelanin and phaeomelanin synthesis in human hair follicles. eumelanin 46-55 tyrosinase Homo sapiens 0-10 1655007-4 1991 The levels of tyrosinase synthesis in the red-haired subjects correlated well with the phaeomelanin content in the hair but in the dark-haired individuals a better correlation was seen with eumelanin. eumelanin 190-199 tyrosinase Homo sapiens 14-24 1900307-6 1991 Quantitative hairbulb tyrosinase (dopa oxidase) assay demonstrated a loss of activity above 35-37 degrees C. Plasma pheomelanin and urine eumelanin intermediates were reduced and correlated with hair melanin content. eumelanin 138-147 tyrosinase Homo sapiens 22-32 34439449-8 2021 Experiments using mushroom TYR suggest that L-cysteinamide at certain concentrations can inhibit eumelanin synthesis through a dual mechanism by inhibiting TYR-catalyzed dopaquinone synthesis and by diverting the synthesized dopaquinone to the formation of DOPA-cysteinamide conjugates rather than dopachrome. eumelanin 97-106 tyrosinase Homo sapiens 156-159 33871027-3 2021 Melanogenesis consists of a series of biochemical and enzymatic reactions catalysed by tyrosinase and other tyrosinase-related proteins, leading to the formation of two types of melanin, eumelanin and pheomelanin. eumelanin 187-196 tyrosinase Homo sapiens 87-97 33871027-3 2021 Melanogenesis consists of a series of biochemical and enzymatic reactions catalysed by tyrosinase and other tyrosinase-related proteins, leading to the formation of two types of melanin, eumelanin and pheomelanin. eumelanin 187-196 tyrosinase Homo sapiens 108-118 30994696-6 2019 The enzyme tyrosinase oxidises tyrosine into 3,4-dihydroxyphenylalanine (DOPA), DOPA-quinone and further products, eventually forming eumelanin. eumelanin 134-143 tyrosinase Homo sapiens 11-21 29374432-4 2017 Tyrosinase is a key enzyme involved in the melanogenesis process, resulting in the formation of black-brown eumelanin and yellow-red feomelanin. eumelanin 108-117 tyrosinase Homo sapiens 0-10 23824587-3 2014 This protein plays a crucial role in melanosome biogenesis, and controls the eumelanin content in melanocytes in part via the processing and trafficking of tyrosinase which is the rate-limiting enzyme in melanin synthesis. eumelanin 77-86 tyrosinase Homo sapiens 156-166 19449448-3 2009 Enzymatic components of melanosomes include tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase, which depend on the functions of OA1, P, MATP, ATP7A, and BLOC-1 to synthesize eumelanins and pheomelanins. eumelanin 193-203 tyrosinase Homo sapiens 44-54 11310792-7 2001 Based on these data, we propose that differentiating KCs start accumulating eumelanins, as a result of previous expression of high levels of tyrosinase and of dopa oxidase activity, acquire the full KC phenotype (characterized by both phagocytic and melanosynthetic ability), and then undergo apoptosis. eumelanin 76-86 tyrosinase Homo sapiens 141-151 11258976-3 2001 L-DOPA, a precursor of eumelanin, was oxidized and oligomerized with tyrosinase. eumelanin 23-32 tyrosinase Homo sapiens 69-79 11171088-7 2001 Therefore, human tyrosinase displays a broader substrate specificity than its mouse counterpart, and might be at least partially responsible for the incorporation of DHICA units into human eumelanins. eumelanin 189-199 tyrosinase Homo sapiens 17-27 7855064-7 1994 This increase in tyrosinase could be related to the greater levels of eumelanin found in skin types III and IV, and this is in keeping with the view that higher levels of tyrosinase are associated with the production of eumelanin than phaeomelanin. eumelanin 70-79 tyrosinase Homo sapiens 17-27 7855064-7 1994 This increase in tyrosinase could be related to the greater levels of eumelanin found in skin types III and IV, and this is in keeping with the view that higher levels of tyrosinase are associated with the production of eumelanin than phaeomelanin. eumelanin 70-79 tyrosinase Homo sapiens 171-181 7855064-7 1994 This increase in tyrosinase could be related to the greater levels of eumelanin found in skin types III and IV, and this is in keeping with the view that higher levels of tyrosinase are associated with the production of eumelanin than phaeomelanin. eumelanin 220-229 tyrosinase Homo sapiens 17-27 7855064-7 1994 This increase in tyrosinase could be related to the greater levels of eumelanin found in skin types III and IV, and this is in keeping with the view that higher levels of tyrosinase are associated with the production of eumelanin than phaeomelanin. eumelanin 220-229 tyrosinase Homo sapiens 171-181 8348959-2 1993 Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. eumelanin 90-99 tyrosinase Homo sapiens 0-10