PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9758418-2	1998	In murine melanocytes, TRP-1 functions as a 5,6-dihydroxyindole-2-carboxylic acid [DHICA] oxidase during the biosynthetic conversion of tyrosine to eumelanin and mutations affecting TRP-1 result in the synthesis of brown rather than black pelage coloration.	eumelanin	148-157	tyrosinase-related protein 1	Mus musculus	23-28	
20633051-8	2010	Tyrosinase-related protein 1 is the rate-limiting enzyme in the production of eumelanin, and possible relationships between eumelanin-expressing cells and thermal nociception are discussed.	eumelanin	78-87	tyrosinase-related protein 1	Mus musculus	0-28	
11171088-3	2001	Conversely, mouse tyrp1, but not tyrosinase, catalyses the oxidation of the indolic intermediate 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into the corresponding 5,6-indolequinone-2-carboxylic acid, thus promoting the incorporation of DHICA units into eumelanin.	eumelanin	256-265	tyrosinase-related protein 1	Mus musculus	18-23	
11041210-1	2000	Tyrosinase related protein-1 (TRP-1) is a melanocyte-specific gene product involved in eumelanin synthesis.	eumelanin	87-96	tyrosinase-related protein 1	Mus musculus	0-28	
11041210-1	2000	Tyrosinase related protein-1 (TRP-1) is a melanocyte-specific gene product involved in eumelanin synthesis.	eumelanin	87-96	tyrosinase-related protein 1	Mus musculus	30-35	
7686498-0	1993	Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes.	eumelanin	0-9	tyrosinase-related protein 1	Mus musculus	79-107	
24521313-1	2014	B (Tyrp1 (+)), the wild type allele at the mouse brown locus, produces black eumelanin, while b (Tyrp1(b) ), the recessive allele, produces brown eumelanin and exhibits lower tyrosinase (Tyr)-related protein 1 (Tyrp1) activity.	eumelanin	146-155	tyrosinase-related protein 1	Mus musculus	97-102	
9447965-2	1998	However, two other enzymes, tyrosinase-related protein 1 (TRP1) and TRP2, are required for a normal melanization process leading to eumelanin synthesis.	eumelanin	132-141	tyrosinase-related protein 1	Mus musculus	28-56	
9447965-2	1998	However, two other enzymes, tyrosinase-related protein 1 (TRP1) and TRP2, are required for a normal melanization process leading to eumelanin synthesis.	eumelanin	132-141	tyrosinase-related protein 1	Mus musculus	58-62	
7686498-7	1993	In all cases, the mRNA levels of tyrosinase and TRP-1 changed in parallel with tyrosinase activity and eumelanin content.	eumelanin	103-112	tyrosinase-related protein 1	Mus musculus	48-53	
7686498-9	1993	These results suggest that the expressions of tyrosinase and TRP-1 genes are coordinately regulated by melanotropic reagents through cAMP-dependent protein kinase and protein kinase C in mouse B16-F1 cells, and that their coordinate expression causes eumelanin biosynthesis.	eumelanin	251-260	tyrosinase-related protein 1	Mus musculus	61-66