PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33686046-5	2021	Results: Atorvastatin increased expression of PPARgamma, PGC-1alpha, HNF-4alpha, FXR, and CYP7A1 in Hep3B cells.	Atorvastatin	9-21	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	90-96	
33050984-6	2021	The co-administration of RAPA and ATV improved the serum lipid profile and raised the expression levels of proteins involved in reverse cholesterol transport (LXRalpha, CYP7A1, ABCG1, PPARgamma, ApoA1) in the liver.	Atorvastatin	34-37	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	169-175	
28533986-8	2017	Atorvastatin increased the expression of Cyp7a1 in the liver, along with FXR and SHP.	Atorvastatin	0-12	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	41-47	
28533986-13	2017	CONCLUSION: Repeated administration of atorvastatin affects bile acid metabolism and markedly increases the expression of the bile acid synthesis rate-limiting enzyme gene Cyp7a1, together with alterations in the expression of circadian clock genes.	Atorvastatin	39-51	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	172-178	
25278499-0	2014	Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice.	Atorvastatin	0-12	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	48-54	
25278499-8	2014	Atorvastatin increased the mRNAs of the BA-synthetic enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) (over 10-fold) and cytochrome P450 27a1, the BA uptake transporters Na+/taurocholate cotransporting polypeptide and organic anion transporting polypeptide 1b2, and the efflux transporter multidrug resistance-associated protein 2 in the liver.	Atorvastatin	0-12	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	61-91	
25278499-8	2014	Atorvastatin increased the mRNAs of the BA-synthetic enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) (over 10-fold) and cytochrome P450 27a1, the BA uptake transporters Na+/taurocholate cotransporting polypeptide and organic anion transporting polypeptide 1b2, and the efflux transporter multidrug resistance-associated protein 2 in the liver.	Atorvastatin	0-12	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	93-99	
25278499-12	2014	The Cyp7a1 induction by atorvastatin appears to be due to suppressed FXR signaling in both the liver and intestine.	Atorvastatin	24-36	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	4-10	
23614904-8	2013	Expression of key liver bile acid synthesis genes CYP7A1 and CYP8B1 were   2.5-fold higher with atorvastatin in both strains, but mRNA for liver bile acid export and reuptake transporters and conjugating enzymes were not unaffected.	Atorvastatin	96-108	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	50-56