PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35335908-0	2022	Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study.	Atorvastatin	88-100	NLR family pyrin domain containing 3	Homo sapiens	143-148	
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Atorvastatin	58-62	NLR family pyrin domain containing 3	Homo sapiens	129-170	
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Atorvastatin	58-62	NLR family pyrin domain containing 3	Homo sapiens	172-177	
27470352-0	2016	Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-kappaB signaling in PMA-stimulated THP-1 monocytes.	Atorvastatin	0-12	NLR family pyrin domain containing 3	Homo sapiens	24-29	
28232172-10	2017	Finally, combined therapy of acetyl-l-carnitine and Lipitor  prevented deposition of cholesterol, formation of CCs, activation of NLRP3, thickening of vessel walls, and elevation of intracranial blood pressure.	Atorvastatin	52-59	NLR family pyrin domain containing 3	Homo sapiens	130-135	
27470352-2	2016	The purpose of the present study was to evaluate the effects of atorvastatin on NLRP3 inflammasome in PMA-stimulated THP-1 cells and explore its underlying mechanism.	Atorvastatin	64-76	NLR family pyrin domain containing 3	Homo sapiens	80-85	
27470352-7	2016	RESULTS: It was shown that atorvastatin significantly reduced the expression of NLRP3, the cleavage of caspase-1 and IL-1beta in PMA-induced THP-1 cells.	Atorvastatin	27-39	NLR family pyrin domain containing 3	Homo sapiens	80-85	
27470352-10	2016	CONCLUSIONS: Atorvastatin exerts an anti-inflammatory effect by inhibiting NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB pathway in PMA-induced THP-1 monocytes.	Atorvastatin	13-25	NLR family pyrin domain containing 3	Homo sapiens	75-80	
23944632-2	2014	The aim of the present study was to determine whether NLRP3 inflammasome is expressed in patients with CAD (coronary artery disease) and whether statins (atorvastatin or rosuvastatin) might affect NLRP3 levels.	Atorvastatin	154-166	NLR family pyrin domain containing 3	Homo sapiens	197-202	
23944632-10	2014	A randomized clinical study has shown that atorvastatin markedly diminished NLRP3 inflammasome levels, whereas rosuvastatin had no impact on these levels.	Atorvastatin	43-55	NLR family pyrin domain containing 3	Homo sapiens	76-81	
23944632-11	2014	Levels of NLRP3 inflammasome decreased in THP-1 cells treated with statins compared with those treated with vehicle, and the fold changes in NLRP3 inflammasome were higher in THP-1 cells treated with atorvastatin compared with those treated with rosuvastatin.	Atorvastatin	200-212	NLR family pyrin domain containing 3	Homo sapiens	10-15	
23944632-11	2014	Levels of NLRP3 inflammasome decreased in THP-1 cells treated with statins compared with those treated with vehicle, and the fold changes in NLRP3 inflammasome were higher in THP-1 cells treated with atorvastatin compared with those treated with rosuvastatin.	Atorvastatin	200-212	NLR family pyrin domain containing 3	Homo sapiens	141-146	
23944632-12	2014	The present study suggests that atorvastatin down-regulates NLRP3 inflammasome expression in CAD, possibly contributing to the inhibitory effects of atorvastatin on chronic inflammation and atherogenic progression in this disorder.	Atorvastatin	32-44	NLR family pyrin domain containing 3	Homo sapiens	60-65	
23944632-12	2014	The present study suggests that atorvastatin down-regulates NLRP3 inflammasome expression in CAD, possibly contributing to the inhibitory effects of atorvastatin on chronic inflammation and atherogenic progression in this disorder.	Atorvastatin	149-161	NLR family pyrin domain containing 3	Homo sapiens	60-65	
23944632-0	2014	NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin.	Atorvastatin	122-134	NLR family pyrin domain containing 3	Homo sapiens	0-5