PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30709876-0 2019 Refractory and metastatic infantile fibrosarcoma harboring LMNA-NTRK1 fusion shows complete and durable response to crizotinib. Crizotinib 116-126 neurotrophic receptor tyrosine kinase 1 Homo sapiens 64-69 30691963-0 2019 Durable Clinical Response to Crizotinib in IRF2BP2-NTRK1 Non-small-cell Lung Cancer. Crizotinib 29-39 neurotrophic receptor tyrosine kinase 1 Homo sapiens 51-56 31213843-0 2019 Complete response to crizotinib in a metastatic adenocarcinoma of unknown primary harboring MET amplification and NTRK1 co-occurring mutation. Crizotinib 21-31 neurotrophic receptor tyrosine kinase 1 Homo sapiens 114-119 30709876-4 2019 In this report, we outline the use of integrative clinical sequencing (ICS) including RNA-seq in a patient with refractory, metastatic IFS to reveal an unusual fusion (LMNA-NTRK1), not detected by routine FISH testing, which was treated with oral crizotinib and resulted in a complete and durable long-term response. Crizotinib 247-257 neurotrophic receptor tyrosine kinase 1 Homo sapiens 173-178 30134855-0 2018 A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report. Crizotinib 142-152 neurotrophic receptor tyrosine kinase 1 Homo sapiens 90-95 30134855-9 2018 CONCLUSIONS: The LMNA-NTRK1 fusion was likely the molecular driver of tumorigenesis and metastasis in this patient, and the observed effectiveness of crizotinib treatment provides clinical validation of this molecular target. Crizotinib 150-160 neurotrophic receptor tyrosine kinase 1 Homo sapiens 22-27 30134855-7 2018 The patient then began treatment with crizotinib at an oral dose of 450 mg per day, based on the detection of a LMNA-NTRK1 fusion gene in the tumor by next-generation sequencing. Crizotinib 38-48 neurotrophic receptor tyrosine kinase 1 Homo sapiens 117-122 33941195-0 2021 Unclassified mesenchymal sarcoma with NTRK1-KHDRBS1 gene fusion: a case report of long-term tumor-free survival with crizotinib treatment. Crizotinib 117-127 neurotrophic receptor tyrosine kinase 1 Homo sapiens 38-43 29125233-7 2017 KM12SM cells were sensitive to the tropomyosin-related kinase-A inhibitors crizotinib and entrectinib. Crizotinib 75-85 neurotrophic receptor tyrosine kinase 1 Homo sapiens 35-63 26563356-0 2016 Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib. Crizotinib 133-143 neurotrophic receptor tyrosine kinase 1 Homo sapiens 101-106