PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27496196-3 2016 Herein, we present a 69-year-old never-smoker Chinese male with advanced lung adenocarcinoma harboring concomitant spectrin beta non-erythrocytic 1 (SPTBN1)-ALK fusion, c-Met overexpression, and human epidermal growth factor receptor-2 (HER-2) amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy. Crizotinib 286-296 spectrin beta, non-erythrocytic 1 Homo sapiens 115-147 27496196-5 2016 Therefore, c-Met overexpression, HER-2 gene amplification, and SPTBN1-ALK gene fusion can coexist in lung adenocarcinoma and may become a potential biomarker of cancer refractory to crizotinib, chemotherapy, and radiotherapy as well as of a relatively poor prognosis. Crizotinib 182-192 spectrin beta, non-erythrocytic 1 Homo sapiens 63-69