PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28217366-0	2017	Crizotinib Inhibits Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4 Activity.	Crizotinib	0-10	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	20-81	
28217366-7	2017	Crizotinib resulted in diminished current density of HCN4, the major molecular determinant of If, with an IC50 of 1.4 +- 0.3 mumol/L.	Crizotinib	0-10	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	53-57	
28217366-8	2017	Crizotinib also slowed HCN4 activation and shifted the activation curve to the left towards more hyperpolarized potentials.	Crizotinib	0-10	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	23-27	
28217366-9	2017	CONCLUSIONS: Our results suggest that crizotinib"s effects on HCN4 channels play a significant role in mediating its observed effects on HR.	Crizotinib	38-48	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	62-66