PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34657149-8	2022	Downstream signaling analysis showed that deletion of PTPN1 or PTPN2 induces resistance to crizotinib by hyperactivating SHP2, the MAPK and JAK/STAT pathways.	Crizotinib	91-101	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	63-68	
34657149-10	2022	Combination of crizotinib with a SHP2 inhibitor synergically inhibited the growth of wild-type or PTPN1/PTPN2 knock-out ALCL, where it reverted TKI resistance.	Crizotinib	15-25	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	104-109