PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28427213-4 2017 The impact of continued crizotinib therapy on the patients" PFS2 time was assessed after adjusting for potential confounding factors. Crizotinib 24-34 GINS complex subunit 2 Homo sapiens 60-64 28427213-6 2017 With continued crizotinib therapy after documentation of PD, the median PFS2 for all 33 patients was 16 weeks, and in those with CNS progression but systemic disease control it was 30 weeks. Crizotinib 15-25 GINS complex subunit 2 Homo sapiens 72-76 28427213-8 2017 Multivariable Cox regression analysis showed that the PFS1 with initial crizotinib treatment and local therapy were independent predictors of PFS2. Crizotinib 72-82 GINS complex subunit 2 Homo sapiens 142-146