PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33597889-0 2021 Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway. Crizotinib 0-10 NFE2 like bZIP transcription factor 2 Homo sapiens 100-104 33597889-8 2021 Furthermore, mechanistic investigations demonstrated that crizotinib and sunitinib accumulated ROS and inhibited Nrf2 signaling, and that ROS scavenger NAC and Nrf2 agonist tBHQ alleviated the extent of cell damage and the mitochondrial apoptosis during crizotinib- and sunitinib-induced hepatotoxicity in L02 cells. Crizotinib 58-68 NFE2 like bZIP transcription factor 2 Homo sapiens 113-117 33597889-8 2021 Furthermore, mechanistic investigations demonstrated that crizotinib and sunitinib accumulated ROS and inhibited Nrf2 signaling, and that ROS scavenger NAC and Nrf2 agonist tBHQ alleviated the extent of cell damage and the mitochondrial apoptosis during crizotinib- and sunitinib-induced hepatotoxicity in L02 cells. Crizotinib 254-264 NFE2 like bZIP transcription factor 2 Homo sapiens 160-164