PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30742941-6	2019	Interestingly, the addition of crizotinib inhibited the expression of phosphorylated ERK1/2 and further augmented anti-CD30-LDM-mediated apoptosis, providing a potential synergistic mechanism for DNA-damaging agents combined with NPM-ALK inhibitors.	Crizotinib	31-41	mitogen-activated protein kinase 3	Homo sapiens	85-91	
30879923-12	2019	Xenograft studies further confirmed that CsA or Erk1/2 inhibitor PD98059 enhanced the anti-cancer activity of crizotinib through inhibition of CaN-Erk1/2 axis.	Crizotinib	110-120	mitogen-activated protein kinase 3	Homo sapiens	48-54	
30879923-12	2019	Xenograft studies further confirmed that CsA or Erk1/2 inhibitor PD98059 enhanced the anti-cancer activity of crizotinib through inhibition of CaN-Erk1/2 axis.	Crizotinib	110-120	mitogen-activated protein kinase 3	Homo sapiens	147-153	
26496080-7	2015	Crizotinib and canertinib both inhibited cell viability and phosphorylation of Akt and ERK1/2.	Crizotinib	0-10	mitogen-activated protein kinase 3	Homo sapiens	87-93	
33887553-9	2021	In combination, sunitinib was able to overcome potential crizotinib-induced resistance through downregulation of ERK 1/2 activity and PDGFRss receptor expression; consequently, tumor growth was significantly decreased both in vitro and in vivo.	Crizotinib	57-67	mitogen-activated protein kinase 3	Homo sapiens	113-120	
31446643-5	2019	AZD9291 resistance was partially restored by combination of AZD9291 and crizotinib only in resistant cells overexpressing phospho-c-Met, which synergistically inhibited c-Met-mediated phosphorylation of the downstream targets ERK1/2 and AKT.	Crizotinib	72-82	mitogen-activated protein kinase 3	Homo sapiens	226-232	
30879923-9	2019	Mechanistically, crizotinib treatment led to the activation of Ca2+-calcineurin (CaN)-Kinase suppressor of Ras 2 (KSR2) signaling, resulting in Erk1/2 activation and enhanced survival of cancer cells.	Crizotinib	17-27	mitogen-activated protein kinase 3	Homo sapiens	144-150	
30879923-11	2019	Similarly, pharmacologic or genetic inhibition of Erk1/2 also enhanced crizotinib-induced growth inhibition in vitro.	Crizotinib	71-81	mitogen-activated protein kinase 3	Homo sapiens	50-56