PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33597889-7	2021	In vivo studies further confirmed that crizotinib and sunitinib decreased mitochondrial membrane potential and activated apoptosis-associated proteins (cleaved-PARP, cleaved caspase3, cytochrome c, Bcl2 and Bax).	Crizotinib	39-49	BCL2 apoptosis regulator	Homo sapiens	198-202	
35155225-8	2022	Crizotinib and sunitinib induced apoptosis via the mitochondrial pathway, which was characterized by decreasing Bcl2/Bax ratio to dissipate the mitochondrial membrane potential, and increasing apoptotic markers levels.	Crizotinib	0-10	BCL2 apoptosis regulator	Homo sapiens	112-116	
29743557-4	2018	We found that combined treatment with ABT263 and Crizotinib synergistically reduces the proliferation of glioblastoma cells, which was dependent on dual inhibition of Bcl-2 and Bcl-xL.	Crizotinib	49-59	BCL2 apoptosis regulator	Homo sapiens	167-172	
32484926-7	2020	Signaling pathways required for crizotinib-induced apoptosis of autophagic cells were explored with flow cytometric analysis, Western blot analysis, short-hairpin RNA knockdown of autophagic proteins, and small-molecule inhibitors of STAT3 and BCL-2.	Crizotinib	32-42	BCL2 apoptosis regulator	Homo sapiens	244-249	
32484926-10	2020	Crizotinib treatment of autophagic cancer cells further enhanced autophagy and induced autophagy-mediated apoptosis by decreasing phosphorylated STAT3 and BCL-2 signaling.	Crizotinib	0-10	BCL2 apoptosis regulator	Homo sapiens	155-160	
30679328-0	2019	Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death.	Crizotinib	12-22	BCL2 apoptosis regulator	Homo sapiens	31-35	
30679328-4	2019	Here, we observed that crizotinib-mediated inactivation of ALK caused an increase in BCL2 levels that restrained the cytotoxic effects of the drug.	Crizotinib	23-33	BCL2 apoptosis regulator	Homo sapiens	85-89	
24486291-0	2014	Crizotinib (PF-2341066) induces apoptosis due to downregulation of pSTAT3 and BCL-2 family proteins in NPM-ALK(+) anaplastic large cell lymphoma.	Crizotinib	0-10	BCL2 apoptosis regulator	Homo sapiens	78-83