PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18654741-6 2008 CONCLUSION: The involvement of secretory transporters P-gp, MRP2 and BCRP, particularly for belotecan, as well as a low passive permeability, appears to be responsible for the low bioavailability of belotecan and topotecan. Topotecan 213-222 PGP Canis lupus familiaris 54-58