PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35201948-7	2022	In summary, IGF1R and MAPK/ERK signaling promotes resistance to CQ/HCQ in PDAC, and their dual inhibition increases sensitivity to autophagy inhibitors.	pdac	74-78	mitogen-activated protein kinase 1	Homo sapiens	27-30	
30833752-6	2019	We conclude that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC.	pdac	204-208	mitogen-activated protein kinase 1	Homo sapiens	87-90	
31076568-7	2019	Our findings underscore an appreciable linkage between YAP transcriptional activation and hypoxic glycolysis governed by ERK2-dependent 14-3-3zeta Ser37 phosphorylation for malignant progression of PDAC.	pdac	198-202	mitogen-activated protein kinase 1	Homo sapiens	121-125	
30833752-6	2019	We conclude that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC.	pdac	204-208	mitogen-activated protein kinase 1	Homo sapiens	91-95	
30833752-6	2019	We conclude that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC.	pdac	204-208	mitogen-activated protein kinase 1	Homo sapiens	157-160	
30041673-16	2018	CONCLUSIONS: This study indicated that KRAS-ERK-mediated transeglin-2 phosphorylation played an important role in the development of PDAC.	pdac	133-137	mitogen-activated protein kinase 1	Homo sapiens	44-47	
23497499-2	2013	Activated Ras oncogene mutations are found in up to 90% of PDAC, leading to activation of the Ras/Raf/MEK/ERK signaling pathway.	pdac	59-63	mitogen-activated protein kinase 1	Homo sapiens	106-109	
26219899-8	2016	In conclusion, CCR7 pathway up-regulates Twist expression via ERK and PI3K/AKT signaling to manage the EMT of PDAC.	pdac	110-114	mitogen-activated protein kinase 1	Homo sapiens	62-65	
28574828-9	2017	Our findings support the clinical development of VS-5584 and ERK inhibitor combination for PDAC treatment.	pdac	91-95	mitogen-activated protein kinase 1	Homo sapiens	61-64	
19433314-8	2009	In summary, our data indicate that, of the uPA system, uPAR exerts the strongest effects on PDAC cells, by acting through the ERK signaling pathway via a positive feedback loop.	pdac	92-96	mitogen-activated protein kinase 1	Homo sapiens	126-129