PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33302036-0 2021 Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway. peoniflorin 0-12 nucleotide-binding oligomerization domain containing 2 Mus musculus 97-101 33302036-3 2021 This work aims to demonstrate that Gram-positive bacteria may be an underlying cause of experimental colitis in mice through the muramyl dipeptide (MDP)-nucleotide-binding oligomerization domain-containing protein-2 (NOD2) pathway and paeoniflorin inhibits the pathway above to alleviate experimental colitis. peoniflorin 235-247 nucleotide-binding oligomerization domain containing 2 Mus musculus 153-215 33302036-7 2021 Paeoniflorin also inhibited mRNA and protein expression of MDP-NOD2 pathway components and decreased the levels of related inflammatory cytokines. peoniflorin 0-12 nucleotide-binding oligomerization domain containing 2 Mus musculus 63-67 33302036-9 2021 Overall, the results indicated that Gram-positive bacteria promote the occurrence of colitis via up-regulation of MDP-NOD2 pathway, and paeoniflorin is able to decrease the infiltration of Gram-positive bacteria in intestine and inhibit Gram-positive bacteria-dependent MDP-NOD2 pathway to alleviate mice colitis. peoniflorin 136-148 nucleotide-binding oligomerization domain containing 2 Mus musculus 274-278