PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35567995-0 2022 ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin. Emodin 74-80 acyl-CoA synthetase long chain family member 4 Homo sapiens 0-5 35567995-9 2022 A docking simulation assay and an MST assay were performed to explore the potential mode of emodin binding to ACSL4. Emodin 92-98 acyl-CoA synthetase long chain family member 4 Homo sapiens 110-115 35567995-14 2022 Docking simulation and MST assay confirmed that emodin can directly bind to ACSL4 target. Emodin 48-54 acyl-CoA synthetase long chain family member 4 Homo sapiens 76-81 35567995-15 2022 Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion. Emodin 66-72 acyl-CoA synthetase long chain family member 4 Homo sapiens 10-15 35567995-15 2022 Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion. Emodin 66-72 acyl-CoA synthetase long chain family member 4 Homo sapiens 212-217 35567995-15 2022 Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion. Emodin 202-208 acyl-CoA synthetase long chain family member 4 Homo sapiens 10-15